Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • Maya BalamaneEmail author
  • Beth Kuczynski
  • Stephanie A. Kolakowsky-Hayner
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1731




An autoreceptor is a receptor located on the neuron (terminals, soma, and/or dendrites), and the function is to bind a specific ligand (such as neurotransmitters or hormones) released by that same neuron. The autoreceptor is mainly used as a feedback mechanism to monitor neurotransmitter synthesis and/or release. In most cases, a negative feedback happens, inhibiting the release of the neurotransmitter. Dopaminergic neurons can have autoreceptors that regulate the release of dopamine. Autoreceptor regulation is very effective in modulating neurotransmission and is of interest for pharmacological intervention.


References and Readings

  1. Carey, R., DePalma, G., Damianopoulos, E., Müller, C., & Huston, J. (2004). The 5-HT1A receptor and behavioral stimulation in the rat: Effects of 8-OHDPAT on spontaneous and cocaine-induced behavior. Psychopharmacology, 177(1/2), 46–54.  https://doi.org/10.1007/s00213-004-1917-4.CrossRefPubMedGoogle Scholar
  2. Meltzer, H. (1980). Relevance of dopamine autoreceptors for psychiatry: Preclinical and clinical studies. Schizophrenia Bulletin, 6(3), 456–475.PubMedCrossRefGoogle Scholar
  3. Schilcker, E., & Feuerstein, F. (2016). Human presynaptic receptors. Pharmacology and Therapeutics.  https://doi.org/10.1016/j.pharmthera.2016.11.005. (in press).CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Maya Balamane
    • 1
    Email author
  • Beth Kuczynski
    • 2
  • Stephanie A. Kolakowsky-Hayner
    • 3
  1. 1.Mount Sinai Brain Injury Research CenterSan FranciscoUSA
  2. 2.Imaging of Dementia and Aging (IDeA) Laboratory, Department of Neurology and Center for NeuroscienceUniversity of CaliforniaDavisUSA
  3. 3.Department of Rehabilitation Medicine, Icahn School of Medicine at Mount SinaiNew YorkUSA