Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • John C. Courtney
  • Cristy Akins
  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1716

Generic Name


Brand Name



Monoamine oxidase inhibitor (MAOI).

Proposed Mechanism(s) of Action

Inhibits the breakdown of norepinephrine, serotonin, and dopamine by irreversible/blocking the enzyme monoamine oxidase.


Major depressive disorder without melancholia.

Off-Label Use

Treatment-resistant depression, panic disorder, and social anxiety disorder.

Side Effects


Liver toxicity, hypertensive crisis, mania, suicidal ideation, and seizures.


Orthostatic hypotension, sexual dysfunction, agitation, anxiety, insomnia, constipation, nausea, diarrhea, vomiting, dry mouth, appetite disturbance, and weight gain.

References and Readings

  1. Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York, NY: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com.

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • John C. Courtney
    • 1
  • Cristy Akins
    • 2
  • Efrain Antonio Gonzalez
    • 3
    • 4
    Email author
  1. 1.Socorro Mental HealthPresbyterian Medical ServicesSocorroUSA
  2. 2.Mercy Family CenterMetarieUSA
  3. 3.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  4. 4.Utah State UniversityLoganUSA