Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • John C. Courtney
  • Cristy Akins
  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1712

Generic Name


Brand Name



Antipsychotics, first generation; phenothiazines

Proposed Mechanism(s) of Action

Inhibits dopamine 2 receptors


Schizophrenia (treatment resistant)

Off-Label Use

Agitation (rarely used) and depressive disorders (rarely used)

Side Effects


Agranulocytosis, significant for QTc prolongation, seizures, ventricular arrhythmia, neuroleptic malignant syndrome, and sudden death


Akathisia, neuroleptic-induced deficit syndrome, extrapyramidal symptoms, priapism, galactorrhea, amenorrhea, pigmentary retinopathy, sexual dysfunction, dry mouth, blurred vision, and weight gain

References and Readings

  1. Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com
  2. Free drug online and PDA Software. www.medscape.com

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • John C. Courtney
    • 1
  • Cristy Akins
    • 2
  • Efrain Antonio Gonzalez
    • 3
    • 4
    Email author
  1. 1.Socorro Mental HealthPresbyterian Medical ServicesSocorroUSA
  2. 2.Mercy Family CenterMetarieUSA
  3. 3.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  4. 4.Utah State UniversityLoganUSA