Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • John C. Courtney
  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1703

Generic Name


Brand Name

Risperdal, Risperdal Consta, and Risperdal M-Tab


Antipsychotics, second generation; antimanic agents

Proposed Mechanism(s) of Action

Blocks dopamine-2 receptors; blocks serotonin 2A receptors, thus increasing presynaptic release of related catecholamines, and hypothetically antagonizes alpha-2 receptors, thus increasing antidepressant properties


Schizophrenia, other psychotic disorders, acute mania, and autism-related irritability in children

Off-Label Use

Bipolar maintenance, bipolar depression, behavioral disturbances in the elderly and children, Tourette syndrome, and PTSD

Side Effects


Hyperglycemia with some cases of ketoacidosis, hyperosmolar coma, or death; cerebrovascular events in the elderly; and neuroleptic malignant syndrome and seizures (rare)


Weight gain and metabolic syndrome, dose-dependent extrapyramidal symptoms, hyperprolactinemia, dizziness, constipation, dry mouth, abdominal pain, nausea, rare...

This is a preview of subscription content, log in to check access.

References and Readings

  1. Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com
  2. Free Drug Online and PDA Software. www.medscape.com

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Socorro Mental HealthPresbyterian Medical ServicesSocorroUSA
  2. 2.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  3. 3.Utah State UniversityLoganUSA