Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Phenytoin

  • John C. Courtney
  • Cristy Akins
  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1694

Generic Name

Phenytoin

Brand Name

Dilantin, Dilantin 125, and Phenytek

Class

Anticonvulsants, hydantoins; antidysrhythmics, Ib

Proposed Mechanism(s) of Action

Sodium channel blocker (blocks voltage-gated dependent sodium channels)

Indication

Generalized tonic-clonic and complex partial seizures and prevention of seizures concurrent with or following neurosurgery

Off-Label Use

No common off-label use

Side Effects

Serious

Agranulocytosis, leukopenia, and Stevens-Johnson syndrome

Common

Ataxia, nystagmus, impaired motor coordination, confusion, insomnia, headaches, tremor, dystonia, rash, nausea, vomiting, and liver dysfunction

References and Readings

  1. Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com
  2. Free Drug Online and PDA Software. www.medscape.com

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • John C. Courtney
    • 1
  • Cristy Akins
    • 2
  • Efrain Antonio Gonzalez
    • 3
    • 4
    Email author
  1. 1.Socorro Mental HealthPresbyterian Medical ServicesSocorroUSA
  2. 2.Mercy Family CenterMetarieUSA
  3. 3.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  4. 4.Utah State UniversityLoganUSA