Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Pentobarbital

  • John C. Courtney
  • Cristy Akins
  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1690

Generic Name

Pentobarbital

Brand Name

Nembutal

Class

Barbiturates; sedative/hypnotics

Proposed Mechanism(s) of Action

Enhances effectiveness of GABA transmission and activates calcium channel

Indication

Seizures, preoperative sedation, and barbiturate coma

Off-Label Use

Reduction of intracranial pressure associated with Reye’s syndrome

Side Effects

Serious

Central nervous system depression, apnea, syncope, and death

Common

Agitation, ataxia, confusion, nervousness, insomnia, anxiety, dizziness, and hypotension

References and Readings

  1. Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free drug online and PDA software. www.epocrates.com
  2. Free drug online and PDA software. www.medscape.com

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • John C. Courtney
    • 1
  • Cristy Akins
    • 2
  • Efrain Antonio Gonzalez
    • 3
    • 4
    Email author
  1. 1.Socorro Mental HealthPresbyterian Medical ServicesSocorroUSA
  2. 2.Mercy Family CenterMetairieUSA
  3. 3.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  4. 4.Utah State UniversityLoganUSA