Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • John C. Courtney
  • Cristy Akins
  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1688

Generic Name


Brand Name

Paxil, Paxil XR, Paxil CR, Brisdelle, and Pexeva


Antidepressants, selective serotonin reuptake inhibitor

Proposed Mechanism(s) of Action

Increases serotonin by blocking the serotonin reuptake pump. Theoretically inhibits muscarinic recycles and blocks nitric oxide synthase Cyp450 260, 2C19, and 3A4 enzymes


Major depressive disorder, obsessive-compulsive disorder, panic disorder, social anxiety disorder, post-traumatic stress disorder, generalized anxiety disorder, premenstrual dysphoric disorder, and menopausal vasomotor symptoms

Off-Label Use

Stuttering, vasovagal syncope, and diabetic neuropathy

Side Effects


Seizures, mania, and suicidal ideation (rare)


Sexual dysfunction, decreased appetite, nausea, dry mouth, insomnia, tremors, agitation, sweating, bruising, bleeding, and hyponatremia

References and Readings

  1. Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free drug online and PDA software. www.epocrates.com
  2. Free Drug Online and PDA Software. www.medscape.com

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • John C. Courtney
    • 1
  • Cristy Akins
    • 2
  • Efrain Antonio Gonzalez
    • 3
    • 4
    Email author
  1. 1.Socorro Mental HealthPresbyterian Medical ServicesSocorroUSA
  2. 2.Mercy Family CenterMetarieUSA
  3. 3.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  4. 4.Utah State UniversityLoganUSA