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Levetiracetam

  • Reference work entry
  • First Online:
Encyclopedia of Clinical Neuropsychology

  • 11 Accesses

Generic Name

Levetiracetam

Brand Name

Keppra XR, Spritam

Class

Anticonvulsant

Proposed Mechanism(s) of Action

Binds to synaptic vesicle protein SV2A and inhibits the activity of negative modulator of GABA and glycine-gated channels; it inhibits N-type calcium current within the neuron.

Indication

Adjunct treatment of partial seizures.

Off-Label Use

Neuropathic pain/chronic pain; mania.

Side Effects

Asthenia, headache, infection, increased blood pressure, drowsiness, fatigue, anorexia, weakness, and nasopharyngitis.

Serious

Suicidal ideation (rare).

Common

Sedation, dizziness, ataxia, asthenia, decreased red blood cell/hemoglobin count, agitation.

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References and Readings

  • Physicians’ Desk Reference (62nd ed.) (2007). Montvale: Thomson PDR.

    Google Scholar 

  • Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.

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Additional Information

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Author information

Authors and Affiliations

  1. College of Psychology, Nova Southeastern University, Fort Lauderdale, FL, USA

    Efrain Antonio Gonzalez

  2. Utah State University, Logan, UT, USA

    Efrain Antonio Gonzalez

Authors
  1. Efrain Antonio Gonzalez
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Corresponding author

Correspondence to Efrain Antonio Gonzalez .

Editor information

Editors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA

    Jeffrey S. Kreutzer

  2. Kessler Foundation, Pleasant Valley Way, West Orange, NJ, USA

    John DeLuca

  3. Independent Practice, Wynnewood, PA, USA

    Bruce Caplan

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© 2018 Springer International Publishing AG, part of Springer Nature

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Gonzalez, E.A. (2018). Levetiracetam. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1669

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