Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Levetiracetam

  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1669

Generic Name

Levetiracetam

Brand Name

Keppra XR, Spritam

Class

Anticonvulsant

Proposed Mechanism(s) of Action

Binds to synaptic vesicle protein SV2A and inhibits the activity of negative modulator of GABA and glycine-gated channels; it inhibits N-type calcium current within the neuron.

Indication

Adjunct treatment of partial seizures.

Off-Label Use

Neuropathic pain/chronic pain; mania.

Side Effects

Asthenia, headache, infection, increased blood pressure, drowsiness, fatigue, anorexia, weakness, and nasopharyngitis.

Serious

Suicidal ideation (rare).

Common

Sedation, dizziness, ataxia, asthenia, decreased red blood cell/hemoglobin count, agitation.

References and Readings

  1. Physicians’ Desk Reference (62nd ed.) (2007). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com.

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  2. 2.Utah State UniversityLoganUSA