Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Levodopa

  • David J. LibonEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1668

Definition

Levodopa or L-DOPA (L-3,4-dihydroxyphenylalanine) is a catecholamine and a precursor of the neurotransmitter dopamine. Neurologic conditions, such as Parkinson’s disease (PD), are often associated with low levels of dopamine. As such levodopa therapy is commonly used to treat PD. Upon crossing the blood-brain barrier, levodopa is converted to dopamine. Increasing brain concentration of dopamine can improve the extrapyramidal syndrome associated with PD. Levodopa is marketed under several brand names including Sinemet. In clinical practice, a number of side effects can occur with levodopa therapy including hallucinations and delusions (Ropper and Samuels 2009).

Cross-References

References and Readings

  1. Ropper, A. H., & Samuels, M. A. (2009). Adams and victor principles of neurology (9th ed.). New York: McGraw Hill.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Departments of Geriatrics, Gerontology, and PsychologyRowan University, New Jersey Institute for Successful Aging, School of Osteopathic MedicineStratfordUSA