Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Lamotrigine

  • Cristy Akins
  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1667

Generic Name

Lamotrigine

Brand Name

Lamictal, Labileno, and Lamictin

Class

Anticonvulsant, mood stabilizer

Proposed Mechanism(s) of Action

Blocks voltage-sensitive sodium channels and inhibits glutamate release.

Indication

Bipolar I disorder (maintenance), partial seizures, and seizures associated with Lennox-Gastaut syndrome.

Off-Label Use

Bipolar depression, bipolar mania, schizophrenia (psychosis), neuropathic pain, and chronic pain.

Side Effects

Dizziness, diplopia, headache, ataxia, blurred vision, rhinitis, somnolence, insomnia, and fatigue.

Serious

Stevens-Johnson rash, organ failure, epidermal necrolysis, drug hypersensitivity, and sudden unexplained death in epileptic patients.

Common

Skin rash, ataxia, headache, tremor, fatigue, sedation, nausea, vomiting, constipation, flu syndrome, pharyngitis, and asthenia.

References and Readings

  1. Physicians’ Desk Reference (62nd ed.). (2007). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software: www.epocrates.com.

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Mercy Family CenterMetarieUSA
  2. 2.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  3. 3.Utah State UniversityLoganUSA