Generic Name
Gabapentin
Brand Name
Neurontin, Gralise
Class
Anticonvulsants, antineuralgic, GABA analogs
Proposed Mechanism(s) of Action
Binds to voltage-sensitive calcium channels via alpha-2 delta subunit, transported across blood-brain barrier and from the gut to the blood via L transport system.
Indication
Partial seizures, postherpetic neuralgia
Off-Label Use
Neuropathic pain, chronic pain, restless legs syndrome, cocaine withdrawal, insomnia, diabetic neuropathy, tremors in multiple sclerosis, hot flashes-cancer related, amyotrophic lateral sclerosis (Orphan), anxiety, and bipolar disorder
Side Effects
Serious
Sudden unexplained deaths associated with epilepsy.
Common
Fatigue, nystagmus, tremor, ataxia, dizziness, sedation, blurred vision, vomiting, diarrhea, constipation, and weight gain.
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References and Readings
Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.
Stahl, S. M. (2007). Essential psychopharmacology: The prescriber's guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Drug Interaction Effects: http://www.drugs.com/drug_interactions.html
Drug Molecule Images: http://www.worldofmolecules.com/drugs/
Free Drug Online and PDA Software: www.epocrates.com
Free Drug Online and PDA Software: www.medscape.com
Gene-Based Estimate of Drug interactions: http://mhc.daytondcs.com:8080/cgi bin/ddiD4?ver = 4&task = getDrugList
Pill Identification: http://www.drugs.com/pill_identification.html
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Courtney, J.C., Akins, C., Gonzalez, E.A. (2018). Gabapentin. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1658
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DOI: https://doi.org/10.1007/978-3-319-57111-9_1658
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