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Donepezil

  • Reference work entry
  • First Online:
Encyclopedia of Clinical Neuropsychology

  • 11 Accesses

Generic Name

Donepezil

Brand Name

Aricept and Aricept ODT

Class

Acetylcholinesterase inhibitors and central

Proposed Mechanism(s) of Action

Reversibly, but noncompetitively, inhibits central acetylcholinesterase, thus making more acetylcholine available at the nerve synapse.

Indication

Alzheimer’s disease

Off-Label Use

Other memory disorders or mild cognitive impairments

Side Effects

Nausea, diarrhea, insomnia, infection, headache, vomiting, cramping, fatigue, anorexia, hypertension, abnormal dreams, confusion, and syncope

Serious

Seizures and syncope (both rare)

Common

Nausea, diarrhea, weight loss, muscle cramps, fatigue, depression, and abnormal dreaming

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References and Readings

  • Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.

    Google Scholar 

  • Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.

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Additional Information

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Author information

Authors and Affiliations

  1. Socorro Mental Health, Presbyterian Medical Services, Socorro, NM, USA

    John C. Courtney

  2. College of Psychology, Nova Southeastern University, Fort Lauderdale, FL, USA

    Efrain Antonio Gonzalez

  3. Utah State University, Logan, UT, USA

    Efrain Antonio Gonzalez

Authors
  1. John C. Courtney
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  2. Efrain Antonio Gonzalez
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Corresponding author

Correspondence to Efrain Antonio Gonzalez .

Editor information

Editors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA

    Jeffrey S. Kreutzer

  2. Kessler Foundation, Pleasant Valley Way, West Orange, NJ, USA

    John DeLuca

  3. Independent Practice, Wynnewood, PA, USA

    Bruce Caplan

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© 2018 Springer International Publishing AG, part of Springer Nature

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Cite this entry

Courtney, J.C., Gonzalez, E.A. (2018). Donepezil. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1651

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