Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • John C. CourtneyEmail author
  • Cristy Akins
  • Efrain Antonio Gonzalez
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1643

Generic Name


Brand Name

Clozaril, Leponex, FazaClo ODT, and Versacloz


Antipsychotics, second generation

Proposed Mechanism(s) of Action

Blocks dopamine 2 receptors and inhibits serotonin 2A receptors, thus increasing presynaptic release of related catecholamines.


Schizophrenia (treatment resistant) and reduction of suicidal behavior.

Off-Label Use

Bipolar disorder (treatment resistant), violence, and aggression associated with psychosis or brain dysfunction.

Side Effects

Hypotension, tachycardia, constipation, nausea, sedation, appetite increase, heartburn, vomiting, and weight gain.


Agranulocytosis, neuroleptic malignant syndrome, seizures, pulmonary embolism, myocarditis, and hyperglycemia.


Increased risk for diabetes, sweating, and increased salivation.

References and Readings

  1. Physicians’ Desk Reference. (2017). (71st ed.). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Drug interaction effects. (n.d.). http://www.drugs.com/drug_interactions.html.
  2. Drug molecule images. (n.d.). http://www.worldofmolecules.com/drugs/.
  3. Free drug online and PDA software. (n.d.-a). www.epocrates.com.
  4. Free Drug Online and PDA software. (n.d.-b). www.medscape.com.
  5. Gene-based estimate of drug interactions. (n.d.). http://mhc.daytondcs.com:8080/cgibin/ddiD4?ver=4&task=getDrugList.
  6. Pill identification. (n.d.). http://www.drugs.com/pill_identification.html.

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • John C. Courtney
    • 1
    Email author
  • Cristy Akins
    • 2
  • Efrain Antonio Gonzalez
    • 3
    • 4
  1. 1.Socorro Mental HealthPresbyterian Medical ServicesSocorroUSA
  2. 2.Mercy Family CenterMetarieUSA
  3. 3.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  4. 4.Utah State UniversityLoganUSA