Generic Name
Clorazepate
Brand Name
Azene, Tranxene, Tranxene SD, and Tranxene T-Tab
Class
Anxiolytics, anticonvulsants, and benzodiazepines
Proposed Mechanism(s) of Action
Binds to benzodiazepine receptors at the GABA-A ligand-gated channel, thus allowing for neuronal hyperpolarization. Benzodiazepines enhance the inhibitory action of GABA via boosted chloride conductance. Clorazepate is also hypothesized to inhibit neuronal activity in amygdala-centered fear circuits.
Indication
Anxiety disorder, symptoms of anxiety, seizures, and acute alcohol withdrawal
Off-Label Use
Partial seizures (as an adjunct)
Side Effects
Serious
Respiratory depression, hepatic dysfunction (rare), renal dysfunction and blood dyscrasias, and grand mal seizures
Common
Sedation, fatigue, depression, dizziness, memory problems, dysinhibition, confusion, ataxia, and slurred speech
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References and Readings
Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.
Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Drug Interaction Effects. http://www.drugs.com/drug_interactions.html
Drug Molecule Images. http://www.worldofmolecules.com/drugs/
Free Drug Online and PDA Software. www.epocrates.com
Free Drug Online and PDA Software. www.medscape.com
Gene-Based Estimate of Drug interactions. http://mhc.daytondcs.com:8080/cgibin/ddiD4?ver=4&task=getDrugList
Pill Identification. http://www.drugs.com/pill_identification.html
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Courtney, J.C., Gonzalez, E.A. (2018). Clorazepate. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1642
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DOI: https://doi.org/10.1007/978-3-319-57111-9_1642
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Online ISBN: 978-3-319-57111-9
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