Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Clorazepate

  • John C. Courtney
  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1642

Generic Name

Clorazepate

Brand Name

Azene, Tranxene, Tranxene SD, and Tranxene T-Tab

Class

Anxiolytics, anticonvulsants, and benzodiazepines

Proposed Mechanism(s) of Action

Binds to benzodiazepine receptors at the GABA-A ligand-gated channel, thus allowing for neuronal hyperpolarization. Benzodiazepines enhance the inhibitory action of GABA via boosted chloride conductance. Clorazepate is also hypothesized to inhibit neuronal activity in amygdala-centered fear circuits.

Indication

Anxiety disorder, symptoms of anxiety, seizures, and acute alcohol withdrawal

Off-Label Use

Partial seizures (as an adjunct)

Side Effects

Serious

Respiratory depression, hepatic dysfunction (rare), renal dysfunction and blood dyscrasias, and grand mal seizures

Common

Sedation, fatigue, depression, dizziness, memory problems, dysinhibition, confusion, ataxia, and slurred speech

References and Readings

  1. Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com
  2. Free Drug Online and PDA Software. www.medscape.com

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Socorro Mental HealthPresbyterian Medical ServicesSocorroUSA
  2. 2.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  3. 3.Utah State UniversityLoganUSA