Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan


  • John C. Courtney
  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1641

Generic Name


Brand Name

Duraclon, Catapres, Catapres-TTS, Clorpres, Jenloga, Kapvay, Nexiclon XR


Antihypertensive; alpha 2 agonists, central-acting; ADHD agents

Proposed Mechanism(s) of Action

Centrally acting alpha 2 agonist



Off-Label Use

Attention deficit hyperactivity disorder, Tourette’s syndrome, anxiety disorders including PTSD and social anxiety disorder, substance withdrawal including opiates and alcohol, smoking cessation, restless legs syndrome, Tourette’s syndrome, dysmenorrhea, postherpetic neuralgia, psychosis, pheochromocytoma, menopausal flushing, clonidine-induced hypersalivation, severe pain in cancer patients

Side Effects


Sinus bradycardia, atrioventricular block during withdrawal, hypertensive, encephalopathy, cerebrovascular accidents, and death


Dry mouth, dizziness, constipation, sedation, major depression, weakness, fatigue, impotence, loss of libido, insomnia, headache, dermatologic reactions, hypotension,...

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References and Readings

  1. Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com
  2. Free Drug Online and PDA Software. www.medscape.com

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Socorro Mental HealthPresbyterian Medical ServicesSocorroUSA
  2. 2.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  3. 3.Utah State UniversityLoganUSA