Generic Name
Clomipramine
Brand Name
Anafranil
Class
Tricyclic antidepressant
Proposed Mechanism(s) of Action
Boosts neurotransmitters serotonin and norepinephrine/noradrelaline; blocks serotonin transporter; apparently desensitizes both serotonin 1A receptors and beta adrenergic receptors.
Indication
Obsessive-compulsive disorder, depression, cataplexy syndrome, premature ejaculation.
Off-Label Use
Anxiety, insomnia, chronic pain.
Side Effects
Serious
Paralytic ileus, hyperthermia, lowered seizure threshold and rare seizures, orthostatic hypotension, sudden death, arrhythmias, tachycardia, QTc prolongation, increased intraocular pressure, hepatic failure, extrapyramidal symptoms, mania, and suicidal ideation.
Common
Blurred vision, constipation, increased appetite, urinary retention, dry mouth, nausea, diarrhea, heartburn, strange taste in mouth, weight gain, fatigue, weakness, dizziness, headache, anxiety, nervousness, restlessness, sedation, sexual dysfunction, sweating.
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Physicians’ desk reference (71st ed.) (2017). Montvale: Thomson PDR.
Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.
Additional Information
Drug Interaction Effects. http://www.drugs.com/drug_interactions.html.
Drug Molecule Images. http://www.worldofmolecules.com/drugs/.
Free Drug Online and PDA Software. www.epocrates.com.
Free Drug Online and PDA Software. www.medscape.com.
Gene-Based Estimate of Drug interactions. http://mhc.daytondcs.com:8080/cgi bin/ddiD4?ver=4&task=getDrugList.
Pill Identification. http://www.drugs.com/pill_identification.html.
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Courtney, J.C., Gonzalez, E.A. (2018). Clomipramine. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1639
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DOI: https://doi.org/10.1007/978-3-319-57111-9_1639
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Publisher Name: Springer, Cham
Print ISBN: 978-3-319-57110-2
Online ISBN: 978-3-319-57111-9
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