Citalopram

Generic Name

Citalopram

Brand Name

Celexa

Class

Antidepressants and selective serotonin reuptake inhibitors

Proposed Mechanism(s) of Action

Citalopram blocks the presynaptic serotonin reuptake pump and desensitizes serotonin receptors, theoretically increasing serotonin neurotransmission. Citalopram is also a mild antihistamine.

Indication

Depression

Off-Label Use

Premenstrual dysphoric disorder, obsessive compulsive disorder, panic disorder, generalized anxiety disorder, posttraumatic stress disorder, social anxiety disorder, alcoholism, binge eating disorder, and hot flashes

Side Effects

Serious

Seizures, mania, and suicidal ideation (all rare)

Common

Sexual dysfunction, gastrointestinal upset, insomnia, sedation, tremor, headache, dizziness, sweating, bruising and very rare bleeding, rare hyponatremia, and a potential for SIADH (syndrome of inappropriate antidiuretic hormone secretion)