Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Antihypertensives

  • Mary Pat MurphyEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1629

Definition

Antihypertensives are pharmacologic agents used to lower blood pressure to normal levels or near normal levels. The initiation and intensity of drug treatment depends on blood pressure level, the individual’s risk factors (smoking, dyslipidemia, diabetes mellitus, older than 60, male, postmenopausal women, and family history of cardiovascular disease for women under 65 and men under 55 years of age), and target organ damage (e.g., strokeor TIA, nephropathy, peripheral artery disease, retinopathy) or cardiovascular disease. Cardiovascular risks decrease when the blood pressure is below 139/89. Typical agents for treating hypertension include diuretics, beta-blockers, ACE (angiotensin-converting enzyme) inhibitors, calcium channel blockers, peripheral alpha selective blockers, central alpha2 agonists, direct vasodilators, and adrenergic antagonists.

Current Knowledge

Hypertension is a risk factor for stroke, myocardial infarction, renal failure, congestive heart failure,...

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References and Readings

  1. August, P. (2003). Initial treatment of hypertension. New England Journal of Medicine, 348, 610–617.PubMedCrossRefPubMedCentralGoogle Scholar
  2. Cranwell-Bruce, L. (2008). Antihypertensives. Medsurg Nursing, 17(5), 337–341.PubMedGoogle Scholar
  3. Ernst, M., & Moser, M. (2009). Use of diuretics in patients with hypertension. New England Journal of Medicine, 361, 2153–2164.PubMedCrossRefPubMedCentralGoogle Scholar
  4. Houston, M. C., Pulliam Meador, B., & Moore Schipani, L. (2000). Handbook of antihypertensive therapy (10th ed.). Philadelphia: Hanley & Belfus.Google Scholar
  5. Staessen, J., & Birkenhager, W. (2005). Evidence that new antihypertensives are superior to older drugs. Lancet, 366(9489), 869–871.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.MSN, CRRNPaoliUSA