Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Amitriptyline

  • Efrain Antonio GonzalezEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1625

Generic Name

Amitriptyline

Brand Name

Elavil, Levate

Class

Tricyclic antidepressant

Proposed Mechanism(s) of Action

Increases available norepinephrine and serotonin, blocks serotonin reuptake, and may desensitize both serotonins 1A and beta adrenergic receptors.

Indication

Depression

Off-Label Use

Postherpetic neuralgia, neuropathic pain, fibromyalgia, headache, eating disorder, and insomnia.

Side Effects

Serious

Paralytic ileus, hyperthermia, lowered seizure threshold, sudden death, cardiac arrhythmias, tachycardia, QTc prolongation, hepatic failure, mania, and potential for activation of suicidal ideation.

Common

Blurred vision, constipation, urinary retention, increased appetite, dry mouth, diarrhea, heartburn, weight gain, fatigue, weakness, dizziness, anxiety, sexual dysfunction, sweating, rash, and itching.

References and Readings

  1. Physicians’ Desk Reference, (71st ed.). (2017). Montvale: Thomson PDR.Google Scholar
  2. Stahl, S. M. (2007). Essential psychopharmacology: The prescriber’s guide (2nd ed.). New York: Cambridge University Press.Google Scholar

Additional Information

  1. Free Drug Online and PDA Software. www.epocrates.com.
  2. Free Drug Online and PDA Software. www.medscape.com.

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.College of PsychologyNova Southeastern UniversityFort LauderdaleUSA
  2. 2.Utah State UniversityLoganUSA