Acquired epileptic aphasia
Landau-Kleffner Syndrome (LKS) is an epileptic encephalopathy that is marked by sudden and relatively rapid onset of aphasia in a child with normal or near normal language development. The acquired aphasia classically begins with a verbal auditory agnosia (VAA), or word deafness, and often progresses to expressive language impairment. Sleep-activated epileptiform abnormalities maximally over the temporal regions are a defining feature. Clinical seizures are evident in most cases, but they are not necessary for the diagnosis.
LKS is considered to be an especially rare epilepsy syndrome, constituting about 0.2% of childhood epilepsy syndromes. Its prevalence, however, has increased in recent years likely due to better awareness. LKS is believed to be almost twice as common in males.
A genetic predisposition for LKS has not been identified. Rather, some have suggested that an underlying autoimmune condition may be responsible for...
- Korkman, M., Granström, M., Appelqvist, K., & Liukkonen, E. (1998). Neuropsychological characteristics of five children with the Landau-Kleffner Syndrome: Dissociation of auditory and phonological discrimination. Journal of the International Neuropsychological Society, 4, 566–575.PubMedCrossRefGoogle Scholar
- Riviello, J. J. (2017). The Landau-Kleffner syndrome and epilepsy with continuous spike-waves during sleep. In J. M. Pellock, D. R. Nordli Jr., R. Sankar, & J. W. Wheless (Eds.), Pellock’s pediatric epilepsy: Diagnosis and therapy (4th ed., pp. 393–406). New York: Demos Medical.Google Scholar
- Titus, J. B. (2017). Neuropsychological assessment of children with Landau-Kleffner syndrome. Journal of Pediatric Epilepsy, 6(1), 62–68.Google Scholar