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Angelman Syndrome

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  • First Online:
Encyclopedia of Clinical Neuropsychology

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Definition

Angelman syndrome is a neurodevelopmental disorder caused by one of several genetic mechanisms involving maternal chromosome 15, specifically the region 15q11.2-13 (Dagli et al. 2015). Common features include microcephaly, seizure disorder, impaired motor skills, and developmental delays. Absent or extremely limited expressive language skills are also commonly observed. Behaviorally, individuals with Angelman syndrome are known for a happy temperament, frequent laughter, inattention/hyperactivity, and stereotyped behaviors; these features have been identified as the most consistent features within this population (Clayton-Smith and Laan 2003).

Categorization

Deletion or mutation of genetic material on chromosome 15q11-13 can result in one of two distinct neurodevelopmental disorders, depending upon whether the genetic material is from the maternal or paternal chromosome. This parent of origin effect is known as “imprinting.” Note that the 15q11-13 region is differently...

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References and Readings

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Author information

Authors and Affiliations

  1. Department of Psychology and the Neuroscience Institute, Georgia State University, Atlanta, GA, USA

    Kristen Smith

  2. Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, USA

    Bonita P. “Bonnie” Klein-Tasman

Authors
  1. Kristen Smith
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  2. Bonita P. “Bonnie” Klein-Tasman
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Corresponding author

Correspondence to Kristen Smith .

Editor information

Editors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Virginia Commonwealth University, Richmond, VA, USA

    Jeffrey S. Kreutzer

  2. Kessler Foundation, Pleasant Valley Way, West Orange, NJ, USA

    John DeLuca

  3. Independent Practice, Wynnewood, PA, USA

    Bruce Caplan

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Smith, K., Klein-Tasman, B.P.“. (2018). Angelman Syndrome. In: Kreutzer, J.S., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-57111-9_1510

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