Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Anterograde Amnesia

  • Ginette LaflecheEmail author
  • Mieke Verfaellie
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_1106

Short Description or Definition

The term “anterograde amnesia” refers to an inability to acquire or retain memories of the ongoing events of one’s life (i.e., autobiographical information) or factual (semantic) information to which one was exposed following the onset of amnesia. In contrast to this, implicit memory (such as the acquisition of simple habits or skills like riding a bicycle) is preserved in amnesia.

Brief Historical Background

Current scientific understanding of anterograde amnesia originated with the study of patient HM. In 1953, at age 27, HM underwent bilateral resection of the medial temporal lobes for alleviation of refractory seizures, which had worsened following a head injury he had suffered at age 9. The resection was successful in reducing his seizures, but, unexpectedly, following the treatment, he was unable to remember his normal daily activities. For example, he could not remember the content of a conversation or even having had a conversation, minutes after...

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References and Readings

  1. Baddeley, A. D. (1995). The psychology of memory. In A. D. Baddeley, B. A. Wilson, & F. N. Watts (Eds.), Handbook of memory disorders (pp. 3–25). New York: John Wiley & Sons.Google Scholar
  2. Corkin, S. (1984). Lasting consequences of bilateral medial temporal lobectomy: Clinical course and experimental findings in H. M. Seminars in Neurology, 4, 249–259.CrossRefGoogle Scholar
  3. Diana, R. A., Yonelinas, A. P., & Ranganath, C. (2007). Imaging recollection and familiarity in the medial temporal lobe: A three-component model. Trends, 11(9), 379–386.Google Scholar
  4. Eichenbaum, H. (2006). Memory binding in hippocampal relational networks. In H. D. Zimmer, A. Mecklinger, & U. Linderberger (Eds.), Handbook of binding and memory: Perspectives from cognitive neuroscience (pp. 25–51). New York: Oxford University Press.Google Scholar
  5. Kessels, R. P. C., & Haan, E. H. F. (2003). Implicit learning in memory rehabilitation: A meta-analysis on errorless learning and vanishing cues methods. Journal of Clinical and Experimental Neuropsychology, 25(6), 805–814.PubMedCrossRefGoogle Scholar
  6. Lezak, M. D., Howieson, D. B., & Loring, D. W. (2004). Neuropsychological assessment (4th ed.). New York: Oxford University Press.Google Scholar
  7. Mayes, A. R., Holdstock, J. S., Isaac, C. L., Hunkin, N. M., & Roberts, N. (2002). Relative sparing of item recognition memory in a patient with adult-onset damage limited to the hippocampus. Hippocampus, 12, 325–340.PubMedCrossRefGoogle Scholar
  8. Scolville, W. B., & Milner, B. (1957). Loss of recent memory after bilateral hippocampal lesions. Journal of Neurology, Neurosurgery and Psychiatry, 20(11), 11–21.CrossRefGoogle Scholar
  9. Squire, L. S. (1994). Declarative and nondeclarative memory: Multiple brain systems supporting learning and memory. In D. L. Schacter & E. Tulving (Eds.), Memory systems 1994 (pp. 203–232). Cambridge, MA: MIT Press.Google Scholar
  10. Steinvorth, S., Levine, B., & Corkin, S. (2005). Medial temporal lobe structures are needed to re-experience remote autobiographical memoires: Evidence from H.M. And W.R. Neuropsychologia, 43, 479–496.PubMedPubMedCentralCrossRefGoogle Scholar
  11. Verfaellie, M., Koseff P., & Alexander, M. P. (2000). Acquisition of novel semantic information in amnesia: effects of lesion location. Neuropsychologia, 38, 484–492.PubMedCrossRefGoogle Scholar
  12. Verfaellie, M., & Keane, M. M. (2002). Impaired and preserved memory processes in amnesia. In L. R. Squire & D. L. Schacter (Eds.), Neuropsychology of memory (3rd ed., pp. 35–46). New York: Guilford Press.Google Scholar
  13. Wechsler, D. (1997). Wechsler memory scale – third edition. Administration and scoring manual. San Antonio: The Psychological Corporation, Pearson, Inc.Google Scholar
  14. Wechsler, D. (2009). Wechsler memory scale – Fourth edition, Administration and scoring manual. San Antonio: The Psychological Corporation, Pearson, Inc.Google Scholar
  15. Zita-Patai, E., Gadian, D. G., Cooper, J. M., Dzieciol, A. M., Mishkin, M., & Vargha-Kadem, F. (2015). Extent of hippocampal atrophy predicts degree of deficit in recall. Proceedings of the National Academy of Sciences, 112(41), 12830–12833.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Memory Disorders Research Center, VA Boston Healthcare System and Boston University School of MedicineBostonUSA