Encyclopedia of Clinical Neuropsychology

2018 Edition
| Editors: Jeffrey S. Kreutzer, John DeLuca, Bruce Caplan

Early-Delayed Effects of Radiation

  • Carol L. ArmstrongEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-57111-9_105

Synonyms

Subacute radiotherapy effects

Definition

Therapeutic ionizing irradiation (RT) affects the nervous system in different biological settings and with different mechanisms that manifest at different time points. The early-delayed phase of RT, also termed subacute, is observed weeks to months after treatment is completed (measured 2–4 months post completion of RT but as early as 2 weeks), whether RT is given alone or combined with chemotherapy. The cognitive effects are transient, and if reversal of symptoms does not occur within weeks to months after treatment is completed, a change in neoplastic process should be considered. In more severe cases, symptoms may be similar to those of the tumor, such as headache, lethargy, and worsening of lateralizing signs. Cognition is affected, but effects are thought to be mild and temporary (Rottenberg 1991; Armstrong et al. 2012), and thus reverse again. L’hermitte’s syndrome sometimes occurs following spinal RT and is thought to be due to...

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Child and Adolescent Psychiatry and Behavioral SciencesThe Children’s Hospital of PhiladelphiaPhiladelphiaUSA