Encyclopedia of Clinical Neuropsychology

Living Edition
| Editors: Jeffrey Kreutzer, John DeLuca, Bruce Caplan

Lewy Bodies

  • Matthew Kraybill
  • Yana Suchy
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-56782-2_503-2

Synonyms

Definition

Lewy bodies (LBs) are an abnormal aggregation of protein that develops inside the cytoplasm of neuronal cells. LBs contain ubiquitin, alpha-synuclein, and other associated enzymes (see section “ Cell Biology” below for more detail) (McKeith 2000). LBs can vary in size from 8 μm to 30 μm in diameter. There may be a single LB or multiple LBs in a particular neuron (Masterman and Swanberg 2003). They are identified microscopically using histologic staining techniques and typically appear as spherical masses that have a dense core with a surrounding halo (see Fig. 1).
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References and Reading

  1. Alvord, E. C., & Forno, L. S. (1992). Pathology. In W. C. Koller (Ed.), Handbook of Parkinson’s disease (pp. 255–284). New York: Marcel Dekker.Google Scholar
  2. Goldmann Gross, R., Siderowf, A., & Hurtig, H. I. (2008). Cognitive impairment in Parkinson’s disease and dementia with Lewy bodies: A spectrum of disease. Neurosignals, 16(1), 24–34.CrossRefPubMedGoogle Scholar
  3. Masterman, D., & Swanberg, M. (2003). Neurologic aspects of dementia with Lewy bodies and Parkinson’s disease with dementia. In P. A. Lichtenberg, D. L. Murman, & A. M. Mellow (Eds.), Handbook of dementia: Psychological, neurological, and psychiatric perspectives. Hoboken: Wiley.Google Scholar
  4. McKeith, I. G. (2000). Spectrum of Parkinson’s disease, Parkinson’s dementia, and Lewy body dementia. Neurologic Clinics, 18(4), 865–902.CrossRefPubMedGoogle Scholar
  5. McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., et al. (1996). Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop. Neurology, 47(5), 1113–1124.CrossRefPubMedGoogle Scholar
  6. McKeith, I. G., Dickson, D. W., Lowe, J., Emre, M., O’Brien, J. T., Feldman, H., et al. (2005). Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium. Neurology, 65(12), 1863–1872.CrossRefPubMedGoogle Scholar
  7. Wakabayashi, K., Tanji, K., Odagiri, S., Miki, Y., Mori, F., & Takahashi, H. (2013). The Lewy body in Parkinson’s disease and related neurodegenerative disorders. Molecular Neurobiology, 47(2), 495–508.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Matthew Kraybill
    • 1
  • Yana Suchy
    • 2
  1. 1.NeuropsychologyCottage Rehabilitation HospitalSanta BarbaraUSA
  2. 2.Department of PsychologyUniversity of UtahSalt Lake CityUSA