Living reference work entry
- 32 Downloads
Lewy bodies (LBs) are an abnormal aggregation of protein that develops inside the cytoplasm of neuronal cells. LBs contain ubiquitin, alpha-synuclein, and other associated enzymes (see section “Cell Biology” below for more detail) (McKeith 2000). LBs can vary in size from 8 μm to 30 μm in diameter. There may be a single LB or multiple LBs in a particular neuron (Masterman and Swanberg 2003). They are identified microscopically using histologic staining techniques and typically appear as spherical masses that have a dense core with a surrounding halo (see Fig. 1).
References and Reading
- Alvord, E. C., & Forno, L. S. (1992). Pathology. In W. C. Koller (Ed.), Handbook of Parkinson’s disease (pp. 255–284). New York: Marcel Dekker.Google Scholar
- Masterman, D., & Swanberg, M. (2003). Neurologic aspects of dementia with Lewy bodies and Parkinson’s disease with dementia. In P. A. Lichtenberg, D. L. Murman, & A. M. Mellow (Eds.), Handbook of dementia: Psychological, neurological, and psychiatric perspectives. Hoboken: Wiley.Google Scholar
- McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., et al. (1996). Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop. Neurology, 47(5), 1113–1124.CrossRefPubMedGoogle Scholar
© Springer International Publishing AG 2018