Living reference work entry
Lewy bodies (LBs) are an abnormal aggregation of protein that develops inside the cytoplasm of neuronal cells. LBs contain ubiquitin, alpha-synuclein, and other associated enzymes (see section “ Cell Biology” below for more detail) (McKeith 2000). LBs can vary in size from 8 μm to 30 μm in diameter. There may be a single LB or multiple LBs in a particular neuron (Masterman and Swanberg 2003). They are identified microscopically using histologic staining techniques and typically appear as spherical masses that have a dense core with a surrounding halo (see Fig. 1).
References and Reading
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- Masterman, D., & Swanberg, M. (2003). Neurologic aspects of dementia with Lewy bodies and Parkinson’s disease with dementia. In P. A. Lichtenberg, D. L. Murman, & A. M. Mellow (Eds.), Handbook of dementia: Psychological, neurological, and psychiatric perspectives. Hoboken: Wiley.Google Scholar
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