Encyclopedia of Clinical Neuropsychology

Living Edition
| Editors: Jeffrey Kreutzer, John DeLuca, Bruce Caplan

Multi-infarct Dementia

  • Holly Rau
  • Yana Suchy
Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-56782-2_495-2



Multi-infarct dementia is a vascular dementia syndrome characterized by cognitive decline resulting from the combined effects of multiple ischemic lesions in the brain. Ischemic lesions include large and small cortical and subcortical infarcts, lacunar infarcts, and diffuse white matter ischemic changes. This particular subtype of vascular dementia, in which multiple infarcts (i.e., dead tissue areas) are present, is contrasted with cognitive impairment caused by other forms of cerebrovascular change (i.e., small vessel dementia, hemorrhagic cerebrovascular dementia, strategic infarct dementia, etc.).

Historical Background

The term multi-infarct dementia, coined by Hachinski in 1974, was initially used to describe dementia due to vascular pathology. In 1985, Loeb introduced the term vascular dementia to refer to a global class...

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References and Readings

  1. Brien, J. T., & Thomas, A. (2015). Vascular dementia. Lancet, 386(10004), 1698–1706.CrossRefGoogle Scholar
  2. Erkinjuntti, T. (2007). Vascular cognitive deterioration and stroke: Review. Cerebrovascular Diseases, 24(1 supp), 189–194.CrossRefPubMedGoogle Scholar
  3. Goetz, C. G. (2007). Textbook of clinical neurology (3rd ed.). Philadelphia: Saunders.Google Scholar
  4. Moore, D. P., & Jefferson, J. W. (2004). Handbook of medical psychiatry (2nd ed.). Philadelphia: Mosby.Google Scholar
  5. Rodríguez García, P. L., & Rodríguez García, D. (2015). Diagnosis of vascular cognitive impairment and its main categories. Neurología, 30(4), 223–239.CrossRefPubMedGoogle Scholar
  6. Smith, G. E., & Bondi, M. W. (2013). Mild cognitive impairment and dementia. New York: Oxford University Press.Google Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Holly Rau
    • 1
  • Yana Suchy
    • 1
  1. 1.Department of PsychologyUniversity of UtahSalt Lake CityUSA