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Alzheimer’s Dementia

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Encyclopedia of Clinical Neuropsychology

Synonyms

Alzheimer’s disease; Early-onset Alzheimer’s disease; Familial Alzheimer’s disease; Late-onset Alzheimer’s disease; Senile dementia of the Alzheimer’s type

Short Description or Definition

One of the leading causes of dementia in late life, Alzheimer’s dementia (AD) is a progressive neurodegenerative disorder characterized by a gradual onset and progressive course, affecting memory and other cognitive domains. Traditionally, a diagnosis of AD is made if the cognitive impairments do not occur exclusively in the context of other conditions that affect cognitive status (e.g., delirium, depression, medication side effects, thyroid malfunction, or certain vitamin deficiencies) and are of sufficient severity to cause impairment in social or occupational functioning. Recent changes to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition(DSM-V), allow a diagnosis of AD under either major or mild neurocognitive disorder. The criteria for major neurocognitive...

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References and Reading

  • 2015 Alzheimer’s. (2015). 2015 Alzheimer’s disease facts and figures. Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association, 11(3), 332–384. https://doi.org/10.1016/j.jalz.2015.02.003

    Article  Google Scholar 

  • American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders: DSM-5. Washington, DC: American Psychiatric Association.

    Book  Google Scholar 

  • Arrighi, H. M., Neumann, P. J., Lieberburg, I. M., & Townsend, R. J. (2010). Lethality of Alzheimer disease and its impact on nursing home placement. Alzheimer Disease and Associated Disorders, 24(1), 90–95. https://doi.org/10.1097/WAD.0b013e31819fe7d1

    Article  PubMed  Google Scholar 

  • Chelune, G. J., & Duff, K. (2013). The assessment of change: Serial assessments in dementia evaluations. In L. D. Ravdin, H. L. Katzen, L. D. Ravdin, & H. L. Katzen (Eds.), Handbook on the neuropsychology of aging and dementia (pp. 43–57). New York: Springer Science + Business Media. https://doi.org/10.1007/978-1-4614-3106-0_4

    Chapter  Google Scholar 

  • Cotelli, M., Manenti, R., & Zanetti, O. (2012). Reminiscence therapy in dementia: A review. Maturitas, 72(3), 203–205.

    Article  PubMed  Google Scholar 

  • Engelhart, M. J., Geerlings, M. I., Ruitenberg, A., Van Swieten, J. C., Hofman, A., Witteman, J. C., & Breteler, M. M. (2002). Dietary intake of antioxidants and risk of Alzheimer disease [abstract]. JAMA, 287(24), 3223–3229. PubMed PMID: 12076218.

    Article  PubMed  Google Scholar 

  • Grabowski, T. J., & Damasio, A. R. (2004). Definition, clinical features and neuroanatomical basis of dementia. In M. M. Esiri, V. M.-Y. Lee, & J. Q. Trojanowski (Eds.), The neuropathology of dementia (2nd ed., pp. 1–33). Cambridge, UK: Cambridge University Press.

    Google Scholar 

  • Hardy, J. (2003). The genetics of Alzheimer’s disease. In K. Iqbal & B. Winblad (Eds.), Alzheimer’s disease and related disorders: Research advances (pp. 151–153). Bucharest: Ana Asian Intl. Acad. of Aging.

    Google Scholar 

  • Hebert, L. E., Weuve, J., Scherr, P. A., & Evans, D. A. (2013). Alzheimer disease in the United States (2010–2050) estimated using the 2010 census. Neurology, 80(19), 1778–1783. https://doi.org/10.1212/WNL.0b013e31828726f5

    Article  PubMed  PubMed Central  Google Scholar 

  • Kawas, C., Resnick, S., Morrison, A., Brookmeyer, R., Corrada, M., Zonderman, A., ..., & Metter, E. (1997). A prospective study of estrogen replacement therapy and the risk of developing Alzheimer’s disease: The Baltimore Longitudinal Study of Aging. Neurology, 48(6), 1517–1521.

    Google Scholar 

  • Kivipelto, M., Ngandu, T., Fratiglioni, L., Viitanen, M., Kåreholt, I., Winblad, B., ..., & Nissinen, A. (2005). Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease. Archives of Neurology, 62(10), 1556–1560. https://doi.org/10.1001/archneur.62.10.1556

  • Knopman, D., & Selnes, O. (2003). Neuropsychology of dementia. In K. M. Heilman & E. Valenstein’s (Eds.), Clinical neuropsychology (4th ed., pp. 574–616). New York: Oxford University Press.

    Google Scholar 

  • Malaspina D., Corcoran C., Schobel, S., Hamilton, S.P. (2008). Epidemiological and genetic aspects of neuropsychiatric disorders. In S.C. Yudofsky and R.E. Hales’ Neuropsychiatry and behavioral neurosciences (5th ed) (pp. 301–362). Washington, DC: American Psychiatric Association Press.

    Google Scholar 

  • McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadlan, E. M. (1984). Clinical diagnosis of Alzheimer’s disease: Report of the NINCDS−ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s disease. Neurology, 34, 939–944.

    Article  PubMed  Google Scholar 

  • McKhann, G. M., Knopman, D. S., Chertkow, H., Hyman, B. T., Jack, C. R., Kawas, C. H., ... & Phelps, C. H. (2011). The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimer’s & Dementia, 7(3), 263–269.

    Google Scholar 

  • Mendez, M. F., & Cummings, J. L. (2003). Dementia a clinical approach (3rd ed.). Philadelphia: Butterworth.

    Google Scholar 

  • Morris, M. C. (2012). Nutritional determinants of cognitive aging and dementia. Proceedings of the Nutrition Society, 71, 1–13. https://doi.org/10.1017/S0029665111003296

    Article  PubMed  Google Scholar 

  • Morris, J. H., & Nagy, Z. (2004). Alzheimer’s disease. In M. M. Esiri, V. M.-Y. Lee, & J. Q. Trojanowski (Eds.), The neuropathology of dementia (2nd ed., pp. 161–206). Cambridge, UK: Cambridge University Press.

    Chapter  Google Scholar 

  • Norton, M. C., Dew, J., Smith, H., Fauth, E., Piercy, K. W., Breitner, J. S., ..., & Welsh-Bohmer, K. (2012). Lifestyle behavior pattern is associated with different levels of risk for incident dementia and alzheimer's disease: The Cache County Study. Journal of The American Geriatrics Society, 60(3), 405–412. https://doi.org/10.1111/j.1532-5415.2011.03860.x

  • Orgogozo, J.-M. (2003). Treatment of Alzheimer’s disease with cholinesterase inhibitors. An update on currently used drugs. In K. Iqbal & B. Winblad (Eds.), Alzheimer’s disease and related disorders: Research advances (pp. 663–675). Bucharest: Ana Asian Intl. Acad. of Aging.

    Google Scholar 

  • Scarmeas, N., Luchsinger, J. A., Schupf, N., Brickman, A. M., Cosentino, S., Tang, M. X., & Stern, Y. (2009). Physical activity, diet, and risk of Alzheimer disease. JAMA: Journal of The American Medical Association, 302(6), 627–637. https://doi.org/10.1001/jama.2009.1144

    Article  PubMed  PubMed Central  Google Scholar 

  • Soininen, H., Kivipelto, M., Laakso, M., & Hiltunen, M. (2003). Genetics, molecular epidemiology and cardiovascular risk factors of Alzheimer’s disease. In K. Iqbal & B. Winblad (Eds.), Alzheimer’s disease and related disorders: Research advances (pp. 53–62). Bucharest: Ana Asian Intl. Acad. of Aging.

    Google Scholar 

  • Tschanz, J. T., Norton, M. C., Zandi, P. P., & Lyketsos, C. G. (2013). The cache county study on memory in aging: Factors affecting risk of Alzheimer’s disease and its progression after onset. International Review of Psychiatry, 25(6), 673–685. https://doi.org/10.3109/09540261.2013.849663

    Article  PubMed  PubMed Central  Google Scholar 

  • Wang, H. X., Xu, W., & Pei, J. J. (2012). Leisure activities, cognition and dementia. Biochimica et Biophysica Acta, 1822(3), 482–491.

    Article  PubMed  Google Scholar 

  • Wengreen, H. J., Neilson, C., Munger, R., & Corcoran, C. (2009). Diet quality is associated with cognitive test performance among aging men and women. Journal of Nutrition, 139, 1944–1949.

    Article  PubMed  PubMed Central  Google Scholar 

  • Zandi, P. P., Anthony, J. C., Hayden, K. M., Mehta, K., Mayer, L., & Breitner, J. S. (2002a). Reduced incidence of AD with NSAID but not H2 receptor antagonists: The cache county study. Neurology, 59(6), 880–886.

    Article  PubMed  Google Scholar 

  • Zandi, P. P., Carlson, M. C., Plassman, B. L., Welsh-Bohmer, K. A., Mayer, L. S., Steffens, D. C., & Breitner, J. S. (2002b). Hormone replacement therapy and incidence of Alzheimer disease in older women: The cache county study. JAMA: Journal of The American Medical Association, 288(17), 2123–2129. https://doi.org/10.1001/jama.288.17.2123

    Article  PubMed  Google Scholar 

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Sanders, C., Matyi, J., Tschanz, J.T., Andersen, A. (2018). Alzheimer’s Dementia. In: Kreutzer, J., DeLuca, J., Caplan, B. (eds) Encyclopedia of Clinical Neuropsychology. Springer, Cham. https://doi.org/10.1007/978-3-319-56782-2_489-2

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  • DOI: https://doi.org/10.1007/978-3-319-56782-2_489-2

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