Encyclopedia of Clinical Neuropsychology

Living Edition
| Editors: Jeffrey Kreutzer, John DeLuca, Bruce Caplan

Anticoagulation

Living reference work entry
DOI: https://doi.org/10.1007/978-3-319-56782-2_2156-2

Synonyms

Definition

Anticoagulation refers to the prevention of blood from clotting. An anticoagulant is a chemical that prevents coagulation. The body contains a number of naturally occurring physiological anticoagulants, but other anticoagulants are used as pharmacological agents to prevent and treat thrombotic disorders such as coronary artery disease causing ischemic heart disease, cerebrovascular disease causing stroke, peripheral arterial disease causing limb ischemia, and venous thromboembolic disease.

Commonly used anticoagulation medications include warfarin (Coumadin®), heparin and low molecular weight heparin compounds such as enoxaparin (Lovenox®), tinzaparin (Innohep®), and dalteparin (Fragmin®). New oral anticoagulants, which use a different mechanism of action, have recently gained widespread use. These medications include apixaban (Eliquis®), dabigatran (Pradaxa®), edoxaban (Savaysa®), and rivaroxaban (Xarelto®).

Current Knowledge

Dosages of...

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References

  1. Dentali, F., Douketis, J. D., Gianni, M., Lim, W., & Crowther, M. A. (2007). Meta-analysis: Anticoagulant prophylaxis to prevent symptomatic venous thromboembolism in hospitalized medical patients. Annals of Internal Medicine, 146, 278–288.CrossRefGoogle Scholar
  2. van der Hulle, T., Kooiman, J., den Exter, P. L., Dekkers, O. M., Klok, F. A., & Huisman, M. V. (2014). Effectiveness and safety of novel oral anticoagulants as compared with vitamin K antagonists in the treatment of acute symptomatic venous thromboembolism: A systematic review and meta-analysis. Journal of Thrombosis and Haemostasis, 12, 320–328.CrossRefGoogle Scholar
  3. Kearon, C., Akl, E. A., Ornelas, J., Blaivas, A., Jimenez, D., et al. (2016). Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report. Chest, 149, 315–352.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Feinberg School of Medicine, Physical Medicine and RehabilitationNorthwestern UniversityChicagoUSA