Side Effects, Contraindications, and Drug-Drug Interactions in the Use of Antiparkinsonian Drugs

  • Etsuro Nakanishi
  • Ryosuke TakahashiEmail author
Living reference work entry


Since anticholinergics were firstly used as an antiparkinsonian drug over half a century ago, a lot of antiparkinsonian drugs have been developed and are now on the market. Although levodopa is most effective and still the gold standard therapy for Parkinson’s disease (PD), its side effects of motor complication such as wearing off and dyskinesia limited its use and prompted the development of novel antiparkinsonian drugs. Dopamine agonists are most commonly used drugs among them, but their serious side effects such as sleep attack and impulsive-compulsive disorders are also well-recognized. In this chapter we focus on the common and specific side effects of antiparkinsonian drugs as well as their clinically important drug-drug interactions.


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Department of NeurologyKyoto University Graduate School of MedicineKyotoJapan

Section editors and affiliations

  • Toshiharu Nagatsu
    • 1
    • 2
  • Akira Nakashima
    • 3
  1. 1.Fujita Health University School of MedicineToyoakeJapan
  2. 2.Institute of Environmental MedicineNagoya UniversityNagoyaJapan
  3. 3.Department of Physiological ChemistryFujita Health University School of MedicineToyoake, AichiJapan

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