The Methyl-CpG-Binding Domain (MBD) Protein Family: An Overview and Dietary Influences

  • Carolina Oliveira GigekEmail author
  • Elizabeth Suchi Chen
  • Gaspar Jesus Lopes-Filho
  • Marilia Arruda Cardoso Smith
Reference work entry


The machinery involved in controlling gene expression via DNA methylation includes DNA methyltransferases and seven methyl-CpG-binding domain (MBD) proteins. By binding to methyl-CpG marks, the MBD proteins can recruit the correct epigenetic machinery to read and to interpret the epigenetic landscape. The MBD family comprises seven proteins: MeCP2 and the MBD1–6, each one with a main function and specific characteristics. The family grouping characteristic is the conserved methyl-binding domain sequence that can recognize a single CpG. Dietary intake contributes to the epigenetic equilibrium by preventing or promoting DNA methylation and influencing epigenetic machinery proteins; expression of transgenerational effects of epigenetic marks and regulators is also addressed.


DNA methylation MeCP2 MBD1 MBD2 MBD3 MBD4 MBD5 MBD6 Methionine Choline Folate High fat Transgenerational epigenetics Offspring 

List of Abbreviations


Bromodomain adjacent to zinc finger domain 2A


Bromodomain adjacent to zinc finger domain 2B


Black raspberries


Breast cancer 1 gene




Deoxyribonucleic acid


DNA methyltransferases


Glucose transporter gene


Histone acetyltransferases


Histone deacetylases


Histone demethylases


High fat


Histone methyltransferases


Imprinting control region


Methyl-CpG-binding domain


Methyl-CpG-binding protein 2




Messenger ribonucleic acid


Nucleosome remodeling and histone deacetylase


Reference sequence database


Really interesting new gene


Suppressor of variegation 3–9, enhancer of zeste, and trithorax group


SET domain bifurcated 1


SET domain bifurcated 1


SET and RING finger-associated domain


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Carolina Oliveira Gigek
    • 1
    • 2
    Email author
  • Elizabeth Suchi Chen
    • 1
  • Gaspar Jesus Lopes-Filho
    • 2
  • Marilia Arruda Cardoso Smith
    • 1
  1. 1.Division of Genetics, Department of Morphology and GeneticsUniversidade Federal de São Paulo (UNIFESP)São PauloBrazil
  2. 2.Division of Surgical Gastroenterology, Department of SurgeryUniversidade Federal de São Paulo (UNIFESP)São PauloBrazil

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