Epigenetic Regulation of Early Nutrition on Immune System

  • Lorella Paparo
  • Rosita Aitoro
  • Rita Nocerino
  • Carmen di Scala
  • Margherita Di Costanzo
  • Linda Cosenza
  • Viviana Granata
  • Roberto Berni Canani
Reference work entry


Diet and gut microbiota are considered two of the most important players in regulating immune system development and function in early life. Many of these effects are mediated by epigenetic mechanisms. The “nutriepigenomics” studies the interaction of nutrients with genome and describes their effect on human health through epigenetic modifications. Dietary fiber modulates gut microbiota and influences short-chain fatty acid production with a beneficial effect on immune system. An increasing number of evidences on epigenetic mechanisms regulated by nutrients are involved in the development of food allergy. New possible strategies, as the choice of dietary treatment, could regulate the epigenome, influencing food allergy disease course.


Diet DNA methylation miRNA Histone Short-chain fatty acids Food allergy 

List of Abbreviations


Cow’s milk allergy


Dendritic cells


Extensively hydrolyzed casein formula


Eosinophilic esophagitis


Food allergy


Genome-wide association study


Histone deacetylase


Lactobacillus rhamnosus GG


Peanut allergy


Prostaglandin E2 synthesis


Polyunsaturated fatty acids


Short-chain fatty acids


Regulatory T cells


Thymic stromal lymphopoietin


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Lorella Paparo
    • 1
  • Rosita Aitoro
    • 1
  • Rita Nocerino
    • 1
  • Carmen di Scala
    • 1
  • Margherita Di Costanzo
    • 1
  • Linda Cosenza
    • 1
  • Viviana Granata
    • 1
  • Roberto Berni Canani
    • 1
    • 2
    • 3
  1. 1.Department of Translational Medical ScienceUniversity of Naples “Federico II”NaplesItaly
  2. 2.European Laboratory for the Investigation of Food Induced Diseases (ELFID)University of Naples “Federico II”NaplesItaly
  3. 3.CEINGE Advanced BiotechnologiesUniversity of Naples “Federico II”NaplesItaly

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