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Nutritional and Epigenetics Implications in Esophageal Cancer

  • Danielle Queiroz Calcagno
  • Kelly Cristina da Silva Oliveira
  • Nina Nayara Ferreira Martins
Reference work entry

Abstract

The effects of diet on the epigenome and its modifications on gene expression can provide a window to understanding carcinogenesis. In this chapter, an update of the most recent studies of nutritional epigenetics and how dietary nutrients affect these target mechanisms in esophageal cancer were performed. One-carbon metabolism nutrients and how a variety of nutrients such as folate, methionine, cobalamin, riboflavin, and vitamin B6 has the potential to perturb DNA and histone methylation patterns in esophageal cancer are reviewed. Additionally, the roles of nutrients such as genistein, epigallocatechin-3-gallate, resveratrol and curcumin as DNA methyltransferase inhibitors and modulators of histone modifications are also discussed in esophageal cancer.

Keywords

Esophageal squamous cell carcinoma Esophageal adenocarcinoma One-carbon metabolism Folate Methionine Cobalamin Riboflavin Vitamin B6 Genistein Epigallocatechin-3-gallate Resveratrol Curcumin 

List of Abbreviations

5mTHF

5,10-Methylenetetrahydrofolate

5-MTHF

5-Methylenetetrahydrofolate

BE

Barrett’s esophagus

COX-2

Cytochrome c oxidase subunit II

DHF

Dihydrofolate

DNMTs

DNA methyltransferases

EAC

Esophageal adenocarcinoma

ESCC

Esophageal squamous cell carcinoma

ERK1/ERK2

Extracellular signal-regulated kinase 1

GERD

Gastroesophageal reflux disease

GSTP1

Glutathione S-transferase Pi 1

HATs

Histone acetyltransferases

HDACs

Histone deacetylases

HDMs

Histone demethylases

HMTs

Histone methyltransferases

hMLH1

Human mutL homolog 1

JUN

Jun proto-oncogene

MAT

Methionine adenosyltransferase

MTR

Methionine synthase

MTR

Methionine synthase

MTHFR

Methylenetetrahydrofolate reductase

MTRR

Methionine synthase reductase

MGMT

O6-Methylguanine DNA methyltransferase

NOTCH-1

Notch homolog 1 gene

PTMs

Posttranslational modifications

RARß

Retinoid acid receptor-p

SAM

S-Adenosylmethionine

SAH

S-Adenosylhomocysteine

SAHH

S-Adenosylhomocysteine hydrolase

SHMT

Serine hydroxymethyltransferase

SNPs

Single nucleotide polymorphisms

THF

Tetrahydrofolate

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Danielle Queiroz Calcagno
    • 1
  • Kelly Cristina da Silva Oliveira
    • 1
  • Nina Nayara Ferreira Martins
    • 2
  1. 1.Núcleo de Pesquisas em OncologiaUniversidade Federal do ParáBelémBrazil
  2. 2.Núcleo de Pesquisas em OncologiaUniversidade Federal do ParáBelemBrazil

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