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Proanthocyanidins and Epigenetics

  • Cinta Bladé
  • Anna Arola-Arnal
  • Anna Crescenti
  • Manuel Suárez
  • Francisca I. Bravo
  • Gerard Aragonès
  • Begoña Muguerza
  • Lluís Arola
Reference work entry

Abstract

Proanthocyanidins, also known as condensed tannins, are the most abundant flavonoids in the human diet. Proanthocyanidins provide beneficial health effects by mitigating inflammation, oxidative stress, and risk factors associated with metabolic syndrome. Moreover, proanthocyanidins protect against cardiovascular disease and some cancers. Though several molecular mechanisms have been suggested to explain the beneficial effects of proanthocyanidins, epigenetic mechanisms have recently emerged as important mediators of the effects of proanthocyanidins. This chapter focuses on studies showing that proanthocyanidins can regulate cell functionality by modulation of miRNA expression, DNA methylation, and histone acetylation and methylation.

Keywords

Proanthocyanidins Procyanidins Flavonoids miRNAs DNA methylation Histone acetylation 

List of Abbreviations

CVD

Cardiovascular disease

DNMT

DNA methyltransferase

FXR

Farnesoid X receptor

HATs

Histone acetyltransferases

HDAC

Histone deacetylases

MAPK

Mitogen-activated protein kinases

MetS

Metabolic syndrome

miRNA

microRNA

NF-κB

Nuclear factor kappa B

PBMCs

Peripheral blood mononuclear cells

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Cinta Bladé
    • 1
  • Anna Arola-Arnal
    • 1
  • Anna Crescenti
    • 2
  • Manuel Suárez
    • 1
  • Francisca I. Bravo
    • 1
  • Gerard Aragonès
    • 1
  • Begoña Muguerza
    • 1
  • Lluís Arola
    • 1
    • 2
  1. 1.Nutrigenomics Research Group, Department of Biochemistry and BiotechnologyUniversitat Rovira i Virgili (URV)TarragonaSpain
  2. 2.Nutrition and Health Research Group, Technological Center for Nutrition and Health (EURECAT-CTNS), Tecnio, Campus of International Excellence Southern Catalonia (CEICS)ReusSpain

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