Handbook of Nanofibers pp 621-648 | Cite as
Electrospun Nanofibrous Scaffolds: A Versatile Therapeutic Tool for Cancer Management
- 986 Downloads
Abstract
According to WHO cancer is the leading cause of mortality and morbidity worldwide with 8.2 million cancer-related deaths in 2012. Nanotechnology deals with creating a new and targeted platform for cancer therapy and diagnostics. Similar to nanoparticle-mediated drug delivery and diagnostic methods nanofibers are also being used for the same purpose. The advantages of using nanofibers are the high loading capacity, large surface area, porosity, biodegradability, cost effective, delivery of multi-model therapeutics etc. One of the most important methods for the synthesis of nanofibers is electrospinning which is based on the stretching of melt solution by electrostatic forces. Similar to the applications in reconstructive surgery and regenerative medicine, nanofibers can be used in cancer diagnostics and therapy. Researchers are trying to develop biosensors using nanofibers which can amplify the signals, improve sensitivity and accuracy of assays. Isolation and detection of circulating tumor cells (CTC) using cell capture based on nanofibers are also under development. Targeted and implantable devices for delivering bioactive components, tissue engineering and magnetic hyperthermia based intelligent nanofiber scaffolds are used in cancer treatment and management. 3D cultures of cancer cells on scaffolds have vital applications in tumor biology as well as anticancer drug screening and development whereas 3D culture and differentiation of Mesenchymal Stem Cells (MSC) on scaffolds have application in cancer surgery and wound healing.
Keywords
Cancer Electrospinning Nanofibers Tissue engineering Hyperthermia Drug deliveryReferences
- 1.M.D.D.A Mandal, “What Causes Cancer?” News-Medical.net, 6 Feb 2017 (Online). Available: http://www.news-medical.net/health/What-causes-cancer.aspx
- 2.“WHO Cancer Control Programme,” World health organization. [Online]. Available: http://www.who.int/cancer/en/. Accessed 26 June 2017
- 3.Anand P, Kunnumakara AB, Sundaram C, Harikumar KB, Tharakan ST, Lai OS, Sung B, Aggarwal BB (2008) Cancer is a preventable disease that requires major lifestyle changes. Pharm Res 25:2097–2116. https://doi.org/10.1007/s11095-008-9661-9CrossRefGoogle Scholar
- 4.Langley RR, Fidler IJ (2011) The seed and soil hypothesis revisited-the role of tumor-stroma interactions in metastasis to different organs. Int J Cancer 128:2527–2535. https://doi.org/10.1002/ijc.26031CrossRefGoogle Scholar
- 5.Sporn MB (2000) Chemoprevention of cancer. Carcinogenesis 21:525–530. https://doi.org/10.1093/carcin/21.3.525CrossRefGoogle Scholar
- 6.Davis ID (2000) An overview of cancer immunotherapy. Immunol Cell Biol 78:179–195. https://doi.org/10.1046/j.1440-1711.2000.00906.x\CrossRefGoogle Scholar
- 7.Narayana A (2014) Applications of nanotechnology in cancer: a literature review of imaging and treatment. J Nucl Med Radiat Ther. https://doi.org/10.4172/2155-9619.1000195
- 8.Balaji A, Vellayappan MV, John AA, Subramanian AP, Jaganathan SK, Supriyanto E, Razak SIA (2015) An insight on electrospun-nanofibers-inspired modern drug delivery system in the treatment of deadly cancers. RSC Adv 5:57984–58004. https://doi.org/10.1039/c5ra07595eCrossRefGoogle Scholar
- 9.Drosou CG, Krokida MK, Biliaderis CG (2016) Encapsulation of bioactive compounds through electrospinning/electrospraying and spray drying: a comparative assessment of food-related applications. Dry Technol 35:139–162. https://doi.org/10.1080/07373937.2016.1162797CrossRefGoogle Scholar
- 10.Liang D, Hsiao BS, Chu B (2007) Functional electrospun nanofibrous scaffolds for biomedical applications. Adv Drug Deliv Rev 59:1392–1412. https://doi.org/10.1016/j.addr.2007.04.021CrossRefGoogle Scholar
- 11.Gu P (2015) Biomedical applications of natural polymer based nanofibrous scaffolds. Int J Med Nano Res. https://doi.org/10.23937/2378-3664/1410010
- 12.Villarreal-Gómez LJCBA, Cornejo-Bravo JM, Vera-Graziano R, Grande D (2015) Electrospinning as a powerful technique for biomedical applications: a critically selected survey. J Biomater Sci Polym Ed 27:157–176. https://doi.org/10.1080/09205063.2015.1116885CrossRefGoogle Scholar
- 13.Ramakrishna S, Fujihara K, Teo W-E, Yong T, Ma Z, Ramaseshan R (2006) Electrospun nanofibers: solving global issues. Mater Today 9:40–50. https://doi.org/10.1016/s1369-7021(06)71389-xCrossRefGoogle Scholar
- 14.Fan Z-Y, Zhao Y-L, Zhu X-Y, Luo Y, Shen M-W, Shi X-Y (2016) Folic acid modified electrospun poly(vinyl alcohol)/polyethyleneimine nanofibers for cancer cell capture applications. Chin J Polym Sci 34:755–765. https://doi.org/10.1007/s10118-016-1792-6CrossRefGoogle Scholar
- 15.Tseng H-C, Lee A-W, Wei P-L, Chang Y-J, Chen J-K (2016) Clinical diagnosis of colorectal cancer using electrospun triple-blend fibrous mat-based capture assay of circulating tumor cells. J Mater Chem B 4:6565–6580. https://doi.org/10.1039/c6tb01359gCrossRefGoogle Scholar
- 16.Zhao Y, Fan Z, Shen M, Shi X (2015) Hyaluronic acid-functionalized electrospun polyvinyl alcohol/polyethyleneimine nanofibers for cancer cell capture applications. Adv Mater Interfaces 2:1500256. https://doi.org/10.1002/admi.201500256CrossRefGoogle Scholar
- 17.Hou S, Zhao L, Shen Q, Yu J, Ng C, Kong X, Wu D, Song M, Shi X, Xu X, Ouyang W-H, He R, Zhao X-Z, Lee T, Brunicardi FC, Garcia MA, Ribas A, Lo RS, Tseng H-R (2013) Polymer nanofiber-embedded microchips for detection, isolation, and molecular analysis of single circulating melanoma cells. Angew Chem 125:3463–3467. https://doi.org/10.1002/ange.201208452CrossRefGoogle Scholar
- 18.Shehata N, Samir E, Gaballah S, Hamed A, Elrasheedy A (2016) Embedded ceria nanoparticles in crosslinked PVA electrospun nanofibers as optical sensors for radicals. Sensors 16:1371. https://doi.org/10.3390/s16091371CrossRefGoogle Scholar
- 19.Kumar S, Rai P, Sharma JG, Sharma A, Malhotra BD (2016) PEDOT:PSS/PVA-nanofibers-decorated conducting paper for cancer diagnostics. Adv Mat Technol 1:1600056. https://doi.org/10.1002/admt.201600056CrossRefGoogle Scholar
- 20.Ali MA, Mondal K, Singh C, Malhotra BD, Sharma A (2015) Anti-epidermal growth factor receptor conjugated mesoporous zinc oxide nanofibers for breast cancer diagnostics. Nanoscale 7:7234–7245. https://doi.org/10.1039/c5nr00194cCrossRefGoogle Scholar
- 21.Zhang Z, Liu S, Qi Y, Zhou D, Xie Z, Jing X, Chen X, Huang Y (2016) Time-programmed DCA and oxaliplatin release by multilayered nanofiber mats in prevention of local cancer recurrence following surgery. J Control Release 235:125–133. https://doi.org/10.1016/j.jconrel.2016.05.046CrossRefGoogle Scholar
- 22.Ma Y, Wang X, Zong S, Zhang Z, Xie Z, Huang Y, Yue Y, Liu S, Jing X (2015) Local, combination chemotherapy in prevention of cervical cancer recurrence after surgery by using nanofibers co-loaded with cisplatin and curcumin. RSC Adv 5:106325–106332. https://doi.org/10.1039/c5ra17230fCrossRefGoogle Scholar
- 23.Yuan Z, Pan Y, Cheng R, Sheng L, Wu W, Pan G, Feng Q, Cui W (2016) Doxorubicin-loaded mesoporous silica nanoparticle composite nanofibers for long-term adjustments of tumor apoptosis. Nanotechnology 27:245101. https://doi.org/10.1088/0957-4484/27/24/245101CrossRefGoogle Scholar
- 24.Wang B, Li H, Yao Q, Zhang Y, Zhu X, Xia T, Wang J, Li G, Li X, Ni S (2016) Local in vitro delivery of rapamycin from electrospun PEO/PDLLA nanofibers for glioblastoma treatment. Biomed Pharmacother 83:1345–1352. https://doi.org/10.1016/j.biopha.2016.08.033CrossRefGoogle Scholar
- 25.Tseng Y-Y, Su C-H, Yang S-T, Huang Y-C, Lee W-H, Wang Y-C, Liu S-C, Liu S-J (2016) Advanced interstitial chemotherapy combined with targeted treatment of malignant glioma in rats by using drug-loaded nanofibrous membranes. Oncotarget. https://doi.org/10.18632/oncotarget.10989
- 26.Sedghi R, Shaabani A, Mohammadi Z, Samadi FY, Isaei E (2017) Biocompatible electrospinning chitosan nanofibers: a novel delivery system with superior local cancer therapy. Carbohydr Polym 159:1–10. https://doi.org/10.1016/j.carbpol.2016.12.011CrossRefGoogle Scholar
- 27.Aggarwal U, Goyal AK, Rath G (2017) Development and characterization of the cisplatin loaded nanofibers for the treatment of cervical cancer. Mater Sci Eng C 75:125–132. https://doi.org/10.1016/j.msec.2017.02.013CrossRefGoogle Scholar
- 28.Irani M, Sadeghi GMM, Haririan I (2017) The sustained delivery of temozolomide from electrospun PCL-Diol-b-PU/gold nanocomposite nanofibers to treat glioblastoma tumors. Mater Sci Eng C 75:165–174. https://doi.org/10.1016/j.msec.2017.02.029CrossRefGoogle Scholar
- 29.Zhou H, Liu X, Wu F, Zhang J, Wu Z, Yin H, Shi H (2016) Preparation, characterization, and antitumor evaluation of electrospun resveratrol loaded nanofibers. J Nanomater 2016:1–11. https://doi.org/10.1155/2016/5918462CrossRefGoogle Scholar
- 30.Ardeshirzadeh B, Anaraki NA, Irani M, Rad LR, Shamshiri S (2015) Controlled release of doxorubicin from electrospun PEO/chitosan/graphene oxide nanocomposite nanofibrous scaffolds. Mater Sci Eng C 48:384–390. https://doi.org/10.1016/j.msec.2014.12.039CrossRefGoogle Scholar
- 31.Jassal M, Sengupta S, Bhowmick S (2015) Functionalization of electrospun poly(caprolactone) fibers for pH-controlled delivery of doxorubicin hydrochloride. J Biomater Sci Polym Ed 26:1425–1438. https://doi.org/10.1080/09205063.2015.1100495CrossRefGoogle Scholar
- 32.Zhu X, Ni S, Xia T, Yao Q, Li H, Wang B, Wang J, Li X, Su W (2015) Anti-neoplastic cytotoxicity of SN-38-loaded PCL/gelatin electrospun composite nanofiber scaffolds against human glioblastoma cells in vitro. J Pharm Sci 104:4345–4354. https://doi.org/10.1002/jps.24684CrossRefGoogle Scholar
- 33.Liu S, Wang X, Zhang Z, Zhang Y, Zhou G, Huang Y, Xie Z, Jing X (2015) Use of asymmetric multilayer polylactide nanofiber mats in controlled release of drugs and prevention of liver cancer recurrence after surgery in mice. Nanomedicine 11:1047–1056. https://doi.org/10.1016/j.nano.2015.03.001CrossRefGoogle Scholar
- 34.Okada T, Niiyama E, Uto K, Aoyagi T, Ebara M (2015) Inactivated Sendai virus (HVJ-E) immobilized electrospun nanofiber for cancer therapy. Materials 9:12. https://doi.org/10.3390/ma9010012CrossRefGoogle Scholar
- 35.Sudakaran SV, Venugopal JR, Vijayakumar GP, Abisegapriyan S, Grace AN, Ramakrishna S (2017) Sequel of MgO nanoparticles in PLACL nanofibers for anti-cancer therapy in synergy with curcumin/β-cyclodextrin. Mater Sci Eng C 71:620–628. https://doi.org/10.1016/j.msec.2016.10.050CrossRefGoogle Scholar
- 36.Kaplan JA, Liu R, Freedman JD, Padera R, Schwartz J, Colson YL, Grinstaff MW (2016) Prevention of lung cancer recurrence using cisplatin-loaded superhydrophobic nanofiber meshes. Biomaterials 76:273–281. https://doi.org/10.1016/j.biomaterials.2015.10.060CrossRefGoogle Scholar
- 37.“Hyperthermia in Cancer Treatment,” National Cancer Institute. [Online]. Available: https://www.cancer.gov/about-cancer/treatment/types/surgery/hyperthermia-fact-sheet. Accessed: 26 June 2017
- 38.Martirosyan KS (2012) Thermosensitive magnetic nanoparticles for self-controlled hyperthermia cancer treatment. J Nanomedicine Nanotechnol. https://doi.org/10.4172/2157-7439.1000e112
- 39.Chen Y-H, Cheng C-H, Chang W-J, Lin Y-C, Lin F-H, Lin J-C (2016) Studies of magnetic alginate-based electrospun matrices cross linked with different methods for potential hyperthermia treatment. Mater Sci Eng C 62:338–349. https://doi.org/10.1016/j.msec.2016.01.070CrossRefGoogle Scholar
- 40.Huang C, Soenen SJ, Rejman J, Trekker J, Chengxun L, Lagae L, Ceelen W, Wilhelm C, Demeester J, Smedt SCD (2012) Magnetic electrospun fibers for cancer therapy. Adv Funct Mater 22:2479–2486. https://doi.org/10.1002/adfm.201102171CrossRefGoogle Scholar
- 41.Lin T-C, Lin F-H, Lin J-C (2012) In vitro feasibility study of the use of a magnetic electrospun chitosan nanofiber composite for hyperthermia treatment of tumor cells. Acta Biomater 8:2704–2711. https://doi.org/10.1016/j.actbio.2012.03.045CrossRefGoogle Scholar
- 42.Kim Y-J, Ebara M, Aoyagi T (2013) A smart hyperthermia nanofiber with switchable drug release for inducing cancer apoptosis. Adv Funct Mater 23:5753–5761. https://doi.org/10.1002/adfm.201300746CrossRefGoogle Scholar
- 43.Severyukhina A, Petrova N, Smuda K, Terentyuk G, Klebtsov B, Georgieva R, Bäumler H, Gorin D (2016) Photosensitizer-loaded electrospun chitosan-based scaffolds for photodynamic therapy and tissue engineering. Colloids Surf B: Biointerfaces 144:57–64. https://doi.org/10.1016/j.colsurfb.2016.03.081CrossRefGoogle Scholar
- 44.Bagó JR, Pegna GJ, Okolie O, Mohiti-Asli M, Loboa EG, Hingtgen SD (2016) Electrospun nanofibrous scaffolds increase the efficacy of stem cell-mediated therapy of surgically resected glioblastoma. Biomaterials 90:116–125. https://doi.org/10.1016/j.biomaterials.2016.03.008CrossRefGoogle Scholar
- 45.Koneru B, Shi Y, Munaweera I, Wight-Carter M, Kadara H, Yuan H, Pasqua AJD, Balkus KJ (2016) Radiotherapeutic bandage for the treatment of squamous cell carcinoma of the skin. Nucl Med Biol 43:333–338. https://doi.org/10.1016/j.nucmedbio.2016.02.010CrossRefGoogle Scholar
- 46.Janani G, Pillai MM, Selvakumar R, Bhattacharyya A, Sabarinath C (2017) An in vitro 3D model using collagen coated gelatin nanofibers for studying breast cancer metastasis. Biofabrication 9:015016. https://doi.org/10.1088/1758-5090/aa5510CrossRefGoogle Scholar
- 47.Guiro K, Patel SA, Greco SJ, Rameshwar P, Arinzeh TL (2015) Investigating breast cancer cell behavior using tissue engineering scaffolds. PLoS One. https://doi.org/10.1371/journal.pone.0118724CrossRefGoogle Scholar
- 48.Nelson MT, Short A, Cole SL, Gross AC, Winter J, Eubank TD, Lannutti JJ (2014) Preferential, enhanced breast cancer cell migration on biomimetic electrospun nanofiber ‘cell highways’. BMC Cancer. https://doi.org/10.1186/1471-2407-14-825
- 49.Kievit FM, Cooper A, Jana S, Leung MC, Wang K, Edmondson D, Wood D, Lee JSH, Ellenbogen RG, Zhang M (2013) Aligned chitosan-polycaprolactone polyblend nanofibers promote the migration of glioblastoma cells. Adv Healthc Mater 2:1651–1659. https://doi.org/10.1002/adhm.201300092CrossRefGoogle Scholar
- 50.Grodecki J, Short AR, Winter JO, Rao SS, Winter JO, Otero JJ, Lannutti JJ, Sarkar A (2015) Glioma-astrocyte interactions on white matter tract-mimetic aligned electrospun nanofibers. Biotechnol Prog 31:1406–1415. https://doi.org/10.1002/btpr.2123CrossRefGoogle Scholar
- 51.Li Y, Sun L, Fu H, Duan X (2016) Facile fabrication of a 3D electrospun fibrous mat by ice-templating for a tumor spheroid culture. Polym Chem 7:6805–6811. https://doi.org/10.1039/c6py01718eCrossRefGoogle Scholar
- 52.Kwak J-Y, Kim T-E, Kim CG, Kim JS, Jin S, Yoon S, Bae H-R, Kim J-H, Jeong YH (2016) Three-dimensional culture and interaction of cancer cells and dendritic cells in an electrospun nano-submicron hybrid fibrous scaffold. Int J Nanomedicine 11:823. https://doi.org/10.2147/ijn.s101846CrossRefGoogle Scholar