Fish as a Model for Research in Space

  • Masahiro Chatani
  • Akira KudoEmail author
Living reference work entry


A new facility for rearing small fish was established in the International Space Station (ISS) in 2012 and the experiments employing medaka fish and zebrafish were performed for studies of revealing the mechanism of bone loss and muscle atrophy under microgravity. Firstly, we introduce all experiments withsmall fish performed in the ISS, and then mainly report recent experiments for medaka fish. Space flight with low gravity shows decrease in bone mineral density. To identify the mechanism of this low density, unique experiments on medaka fish were performed twice at the ISS. One was a long-term experiment for the analysis of bone growth, which revealed a decrease in the mineral density. Another was a short-term experiment for live imaging of medaka transgenic lines followed by transcriptome analyses, which revealed increased expressions of five genes.


Gravity Medaka Space Bone Osteoclast Osteoblast 



This work was supported by grants-in-aid for scientific research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan (16K15778 and 16H01635).


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of Pharmacology, School of DentistryShowa UniversityTokyoJapan
  2. 2.International FrontierTokyo Institute of TechnologyTokyoJapan

Section editors and affiliations

  • Luis Zea
    • 1
  1. 1.Assistant Research Professor, BioServe Space TechnologiesUniversity of ColoradoBoulderUSA

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