Obesity pp 227-241 | Cite as

Obesity, Hypertension, and Dyslipidemia

  • Vasilios KotsisEmail author
  • Christina Antza
  • Giannis Doundoulakis
  • Stella Stabouli
Reference work entry
Part of the Endocrinology book series (ENDOCR)


Hypertension and dyslipidemia are closely related with obesity. Obesity releases nonesterified fatty acids into the circulation, increasing fasting plasma triglycerides, reducing high-density lipoprotein cholesterol, and inducing a shift to a proatherogenic composition (small, dense) of low-density lipoproteins. Obesity activates the sympathetic nervous system, increases sodium and water reabsorption, and increases the production of angiotensin II factors that determine hypertension shift in obese people.


Obesity Hypertension 


24 h ABPM

24 hour ambulatory blood pressure monitoring


Angiotensin; RAS: Rennin–Ang system


Body Mass Index


Blood pressure


Free fatty acids


High-density lipoprotein


Intermediate density lipoproteins


Low-density lipoprotein




Metabolic syndrome


Non-alcoholic fatty liver disease


Proprotein convertase subtilisin/kexin type 9




Sympathetic nervous system






Very low density lipoproteins


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Vasilios Kotsis
    • 1
    Email author
  • Christina Antza
    • 1
  • Giannis Doundoulakis
    • 1
  • Stella Stabouli
    • 1
  1. 1.Aristotle University of ThessalonikiThessalonikiGreece

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