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Skin Drug Reactions

  • George-Sorin Tiplica
  • Carmen Maria Salavastru
  • Ionela ManoleEmail author
  • Mihaela Tovaru
Living reference work entry
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Abstract

Drug-induced reactions can be associated with multiple cutaneous manifestations. Most are relatively benign and resolve after a drug is withdrawn, but severe, potentially life-threatening eruptions including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia, and systemic symptoms can occur. Many factors interact to determine the probability of a drug to induce a skin adverse event; they are divided in two main categories including drug factors (molecular size of the drug and route of administration) and host factors (age, gender, genetics, associated diseases, and environmental factors). These reactions are attributed to immunologic mechanisms including hypersensitivity reactions type I (IgE-dependent), type II (antibody-dependent), type III (immune complex-mediated), and type IV (cell-mediated) as well as non-immunological mechanism.

Keywords

Skin drug reaction Drug-induced reaction Adverse drug reaction Exanthematous eruption Maculopapular eruption Morbilliform eruption Urticarial eruption Anaphylaxis Anaphylactoid reaction Photosensitivity Drug-induced phototoxic reaction Drug-induced photoallergic reaction Drug-induced porphyria cutanea tarda Drug-induced vasculitis Acneiform eruption Pustular eruption Acute generalized exanthematous pustulosis Stevens-Johnson syndrome Toxic epidermal necrolysis Lyell syndrome Drug-induced pseudoporphyria Drug-induced linear IgA disease Drug-induced pemphigus Pemphigus foliaceus Pemphigus vulgaris Drug-induced bullous pemphigoid Fixed drug eruption Anticoagulant-induced skin necrosis Warfarin-induced skin necrosis Drug-induced lichenoid eruption Drug-induced cutaneous pseudolymphoma Drug-induced lupus erythematosus Drug-induced alopecia Alopecia areata Telogen effluvium Anagen effluvium Drug-induced hirsutism Drug-induced hypertrichosis Drug-induced hair discoloration Xerostomia Stomatitis Mucosal hyperpigmentation Gingival hyperplasia Skin hyperpigmentation Skin hypopigmentation Purpura Purpura simplex Thrombotic thrombocytopenic purpura Erythema annulare centrifugum Psoriasiform eruption Exfoliative dermatitis Exfoliative dermatitis Erythroderma DRESS syndrome Eczematous eruption Scleroderma-like reaction Erythema nodosum Beau’s line Onychomadesis Leukonychia Melanonychia Mee’s line Muehrcke’s line Onycholysis Photo-onycholysis Subungual hemorrhage Paronychia Periungual pyogenic granuloma Jarisch-Herxheimer reaction 

References

  1. Agarwal R, Peters TJ, Coombes RC, Vigushin DM (2002) Tamoxifen-related porphyria cutanea tarda. Med Oncol 19(2):121–123PubMedCrossRefGoogle Scholar
  2. Agrawal AA (2015) Gingival enlargements: differential diagnosis and review of literature. World J Clin Cases 3(9):779–788PubMedPubMedCentralCrossRefGoogle Scholar
  3. Beacher NG, Brodie MJ, Goodall C (2015) A case report: retigabine induced oral mucosal dyspigmentation of the hard palate. BMC Oral Health 15(1):122PubMedPubMedCentralCrossRefGoogle Scholar
  4. Berger TG, Franklin N (1992) Anaphylactoid reaction to ciprofloxacin in a patient infected with the human immunodeficiency virus. J Am Acad Dermatol 26(2):256–257PubMedCrossRefGoogle Scholar
  5. Bharti V, Bansal C (2013) Drug-induced gingival overgrowth: the nemesis of gingiva unravelled. J Indian Soc Periodontol 17(2):182–187PubMedPubMedCentralCrossRefGoogle Scholar
  6. Bigby M (2001) Rates of cutaneous reactions to drugs. Arch Dermatol 137(6):765–770PubMedGoogle Scholar
  7. Biscoe AL, Bedlow A (2013) Warfarin-induced skin necrosis diagnosed on clinical grounds and treated with maggot debridement therapy. BMJ Case Rep 2013:pii: bcr2012007455CrossRefGoogle Scholar
  8. Blaya M, Saba N (2011) Chemotherapy-induced hyperpigmentation of the tongue. N Engl J Med 365(10):e20PubMedCrossRefGoogle Scholar
  9. Boras VV, Andabak-Rogulj A, Brailo V, Šimunković SK, Gabrić D, Vrdoljak DV (2015) Adverse drug reactions in the oral cavity. Acta Clin Croat 54(2):208–215PubMedGoogle Scholar
  10. Brauer J, Votava HJ, Meehan S, Soter NA (2009) Lichenoid drug eruption. Dermatol Online J 15(8):13PubMedGoogle Scholar
  11. Brenner S, Bialy-Golan A, Ruocco V (1998) Drug-induced pemphigus. Clin Dermatol 16(3):393–397PubMedCrossRefGoogle Scholar
  12. Brown T, Zirvi M, Cotsarelis G, Gelfand JM (2005) Vitiligo-like hypopigmentation associated with imiquimod treatment of genital warts. J Am Acad Dermatol 52(4):715–716PubMedCrossRefGoogle Scholar
  13. Cabanillas M, Peteiro C, Toribio J (2006) Multiple myeloma associated with porphyria cutanea tarda: A possible role of bortezomib? Dermatology 213(3):246–247PubMedCrossRefGoogle Scholar
  14. Cardoso CS, Vieira AM, Oliveira AP (2011) DRESS syndrome: a case report and literature review. BMJ Case Rep 2011:pii: bcr0220113898Google Scholar
  15. Chanal J, Ingen-Housz-Oro S, Ortonne N, Duong TA, Thomas M, Valeyrie-Allanore L, Wolkenstein P (2013) Linear IgA bullous dermatosis: comparison between the drug-induced and spontaneous forms. Br J Dermatol 169(5):1041–1048PubMedCrossRefGoogle Scholar
  16. Cho YT, Lin JW, Chen YC, Chang CY, Hsiao CH, Chung WH, Chu CY (2014) Generalized bullous fixed drug eruption is distinct from Stevens-Johnson syndrome/toxic epidermal necrolysis by immunohistopathological features. J Am Acad Dermatol 70(3):539–548PubMedCrossRefGoogle Scholar
  17. Cox NH, Piette WW (2010) Purpura and microvascular occlusion. In: Burns T, Breathnach S, Cox N, Griffiths C (eds) Rook’s textbook of dermatology, 8th edn. Wiley-Blackwell, Oxford, pp 49.1–49.51Google Scholar
  18. Daniel CR, Scher RK (1984) Nail changes secondary to systemic drugs or ingestants. J Am Acad Dermatol 10(2 Pt 1):250–258PubMedCrossRefGoogle Scholar
  19. Daunton A, Farquharson NR, Coulson IH (2017) Drug eruptions. Medicine 45(7):422–428CrossRefGoogle Scholar
  20. de Melo Filho MR, da Silva CAD, da Rocha Dourado M, de Oliveira Pires MB, Pêgo SPB, de Freitas EM (2012) Palate hyperpigmentation caused by prolonged use of the anti-malarial chloroquine. Head Neck Pathol 6(1):48–50PubMedCrossRefGoogle Scholar
  21. Demitsu T, Manabe M, Harima N, Sugiyama T, Yoneda K, Yamada N (2001) Hypertrichosis induced by latanoprost. J Am Acad Dermatol 44(4):721–723PubMedCrossRefGoogle Scholar
  22. Du-Thanh A, Kluger N, Bensalleh H, Guillot B (2011) Drug-induced acneiform eruption. Am J Clin Dermatol 12(4):233–245PubMedCrossRefGoogle Scholar
  23. Femiano F, Lanza A, Buonaiuto C, Gombos F, Rullo R, Festa V, Cirillo N (2008) Oral manifestations of adverse drug reactions: guidelines. J Eur Acad Dermatol Venereol 22(6):681–691PubMedCrossRefGoogle Scholar
  24. Ferran M, Calvet J, Almirall M, Pujol RM, Maymó J (2011) Alopecia areata as another immune- mediated disease developed in patients treated with tumour necrosis factor α blocker agents. J Eur Acad Dermatol Venereol 25(4):479–484PubMedCrossRefGoogle Scholar
  25. Fiorentino DF (2003) Cutaneous vasculitis. J Am Acad Dermatol 48(3):311–344PubMedCrossRefGoogle Scholar
  26. Gharibi L, Zouhair K, Ramdani B, Benchikhi H (2009) Hair lightening in an hemodialysis patient treated by heptaminol (heptamyl). Dermatol Online J 15(4):16PubMedGoogle Scholar
  27. Gilbar P, Hain A, Peereboom VM (2009) Nail toxicity induced by cancer chemotherapy. J Oncol Pharm Pract 15(3):143–155PubMedCrossRefGoogle Scholar
  28. Goldberg I, Kashman Y, Brenner S (1999) The induction of pemphigus by phenol drugs. Int J Dermatol 38(12):888–892PubMedCrossRefGoogle Scholar
  29. Gould JW, Mercurio MG, Elmets CA (1995) Cutaneous photosensitivity diseases induced by exogenous agents. J Am Acad Dermatol 33(4):551–573PubMedCrossRefGoogle Scholar
  30. Green D, Friedman KJ (2001) Treatment of minocycline-induced cutaneous pigmentation with the Q-switched Alexandrite laser and a review of the literature. J Am Acad Dermatol 44(2 Suppl):342–347PubMedCrossRefGoogle Scholar
  31. Green JJ, Manders SM (2001) Pseudoporphyria. J Am Acad Dermatol 44(1):100–108PubMedCrossRefGoogle Scholar
  32. Guggenheimer J, Moore PA (2003) Xerostomia: etiology, recognition and treatment. J Am Dent Assoc 134(1):61–69PubMedCrossRefGoogle Scholar
  33. Guggina LM, Choi AW, Choi JN (2017) EGFR inhibitors and cutaneous complications: a practical approach to management. Oncol Ther 5(2):135–148CrossRefGoogle Scholar
  34. Gul Mert G, Incecik F, Gunasti S, Herguner O, Altunbasak S (2013) Psoriasiform drug eruption associated with sodium valproate. Case Rep Pediatr 2013:823469PubMedPubMedCentralGoogle Scholar
  35. Harr T, French LE (2010) Toxic epidermal necrolysis and Stevens-Johnson syndrome. Orphanet J Rare Dis 5(1):39PubMedPubMedCentralCrossRefGoogle Scholar
  36. Hautmann G, Lotti T (2003) Psychoactive drugs and skin. J Eur Acad Dermatol Venereol 17(4):383–393PubMedCrossRefPubMedCentralGoogle Scholar
  37. Hertz RS, Beckstead PC, Brown WJ (1980) Epithelial melanosis of the gingiva possibly resulting from the use of oral contraceptives. J Am Dent Assoc 100(5):713–714PubMedCrossRefPubMedCentralGoogle Scholar
  38. Hiatt KM, Horn TD (2009) Cutaneous toxicities of drugs. In: Elder DE (ed) Lever’s histopathology of the skin, 10th edn. Lippincott Williams & Wilkins, Philadelphia, pp 311–331Google Scholar
  39. Husain Z, Reddy BY, Schwartz RA (2013a) DRESS syndrome: Part I. Clinical perspectives. J Am Acad Dermatol 68(5):693.e1–693.e14CrossRefGoogle Scholar
  40. Husain Z, Reddy BY, Schwartz RA (2013b) DRESS syndrome: Part II. Management and therapeutics. J Am Acad Dermatol 68(5):709.e1–709.e9CrossRefGoogle Scholar
  41. Jayakaran TG (2014) The effect of drugs in the oral cavity-a review. J Pharm Sci Res 6(2):89–96Google Scholar
  42. Jinbu Y, Demitsu T (2014) Oral ulcerations due to drug medications. Jpn Dent Sci Rev 50(2):40–46CrossRefGoogle Scholar
  43. Kakagia DD, Papanas N, Karadimas E, Polychronidis A (2014) Warfarin-induced skin necrosis. Ann Dermatol 26(1):96–98PubMedPubMedCentralCrossRefGoogle Scholar
  44. Kakar R, Paugh H, Jaworsky C (2013) Linear IgA bullous disease presenting as toxic epidermal necrolysis: a case report and review of the literature. Dermatology 227(3):209–213PubMedCrossRefGoogle Scholar
  45. Kato K, Satoh T, Nishizawa A, Yokozeki H (2011) Psoriasiform drug eruption due to abatacept. Acta Derm Venereol 91(3):362–363PubMedCrossRefGoogle Scholar
  46. Lazzarini R, Capareli GC, Buense R, Lellis RF (2014) Alopecia universalis during treatment with leflunomide and adalimumab-case report. An Bras Dermatol 89(2):320–322PubMedPubMedCentralCrossRefGoogle Scholar
  47. Lee A, Thomson J (2006) Drug-induced skin reactions. In: Lee A (ed) Adverse drug reactions, 2nd edn. Pharmaceutical Press, London, pp 125–156Google Scholar
  48. Lehloenya RJ, Todd G, Mogotlane L, Gantsho N, Hlela C, Dheda K (2012) Lichenoid drug reaction to antituberculosis drugs treated through with topical steroids and phototherapy. J Antimicrob Chemother 67(10):2535–2537PubMedPubMedCentralCrossRefGoogle Scholar
  49. Llau ME, Viraben R, Montastruc JL (1995) Drug-induced alopecia: review of the literature. Therapie 50(2):145–150PubMedGoogle Scholar
  50. Lyne A, Creedon A, Bailey BM (2015) Mucosal pigmentation of the hard palate in a patient taking imatinib. BMJ Case Rep 2015:pii: bcr2015209335CrossRefGoogle Scholar
  51. Martín-García RF, Camacho NDR, Sánchez JL (2003) Chloroquine-induced, vitiligo-like depigmentation. J Am Acad Dermatol 48(6):981–983PubMedCrossRefGoogle Scholar
  52. Masood I, Bhargava R, Ahmed Z, Sharma DK, Rehman SZ, Amin SS (2005) Gatifloxacin-induced purpura-an unusual adverse drug reaction. J Indian Acad Clin Med 6(3):239–240Google Scholar
  53. Mas-Vidal A, Coto-Segura P, García-Varona A, Santos-Juanes J (2010) Porphyria cutanea tarda induced by olmesartan. J Eur Acad Dermatol Venereol 24(8):977–978PubMedCrossRefGoogle Scholar
  54. McNutt NS, Moreno A, Contreras F (2009) Inflammatory diseases of the subcutaneous fat. In: Elder DE (ed) Lever’s histopathology of the skin, 10th edn. Lippincott Williams & Wilkins, Philadelphia, pp 509–538Google Scholar
  55. Minni J, Sarro R (2006) A novel therapeutic approach to erythema annulare centrifugum. J Am Acad Dermatol 54(3 Suppl 2):S134–S135PubMedCrossRefGoogle Scholar
  56. Mockenhaupt M, Viboud C, Dunant A, Naldi L, Halevy S, Bavinck JNB, Flahault A (2008) Stevens–Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study. J Invest Dermatol 128(1):35–44PubMedCrossRefGoogle Scholar
  57. Montañez MI, Mayorga C, Bogas G, Barrionuevo E, Fernandez-Santamaria R, Martin-Serrano A, Doña I (2017) Epidemiology, mechanisms, and diagnosis of drug-induced anaphylaxis. Front Immunol 8:614PubMedPubMedCentralCrossRefGoogle Scholar
  58. Mortazavi H, Baharvand M, Movahhedian A, Mohammadi M, Khodadoustan A (2014) Xerostomia due to systemic disease: a review of 20 conditions and mechanisms. Ann Med Health Sci Res 4(4):503–510PubMedPubMedCentralCrossRefGoogle Scholar
  59. Mravak-Stipetić M (2012) Xerostomia-diagnosis and treatment. Rad Hrvatske Akademije Znanosti i Umjetnosti Medicinske Znanosti 511(38):69–91Google Scholar
  60. Mubki T, Rudnicka L, Olszewska M, Shapiro J (2014) Evaluation and diagnosis of the hair loss patient: part I History and clinical examination. J Am Acad Dermatol 71(3):415.e1–415.e15CrossRefGoogle Scholar
  61. Murad AA, Daly T, Mulligan N, Lenane P (2014) Extensive warfarin-induced skin necrosis successfully treated with negative pressure wound therapy. BMJ Case Rep 2014:pii: bcr2013203510CrossRefGoogle Scholar
  62. Özkaya E (2013) Oral mucosal fixed drug eruption: characteristics and differential diagnosis. J Am Acad Dermatol 69(2):e51–e58PubMedCrossRefPubMedCentralGoogle Scholar
  63. Pang BK, Su D, Ratnam KV (1993) Drug-induced purpura simplex: clinical and histological characteristics. Ann Acad Med Singap 22(6):870–872PubMedGoogle Scholar
  64. Pereira FA, Mudgil AV, Rosmarin DM (2007) Toxic epidermal necrolysis. J Am Acad Dermatol 56(2):181–200PubMedCrossRefGoogle Scholar
  65. Piraccini BM, Iorizzo M, Tosti A (2003) Drug-induced nail abnormalities. Am J Clin Dermatol 4(1):31–37PubMedCrossRefGoogle Scholar
  66. Ploysangam T, Breneman DL, Mutasim DF (1998) Cutaneous pseudolymphomas. J Am Acad Dermatol 38(6 Pt 1):877–895PubMedCrossRefGoogle Scholar
  67. Pretel M, Marquès L, España A (2014) Drug-induced lupus erythematosus. Actas Dermosifiliogr 105(1):18–30PubMedCrossRefGoogle Scholar
  68. Ramachandran SM, Leventhal JS, Franco LG, Mir A, Walters RF, Franks AG (2017) Topical drug-induced subacute cutaneous lupus erythematosus isolated to the hands. Lupus Sci Med 4(1):e000207PubMedPubMedCentralCrossRefGoogle Scholar
  69. Reyes-Habito CM, Roh EK (2014a) Cutaneous reactions to chemotherapeutic drugs and targeted therapies for cancer: part I Conventional chemotherapeutic drugs. J Am Acad Dermatol 71(2):203.e1–203.e12CrossRefGoogle Scholar
  70. Reyes-Habito CM, Roh EK (2014b) Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer: part II Targeted therapy. J Am Acad Dermatol 71(2):217.e1–217.e11CrossRefGoogle Scholar
  71. Ricci F, De Simone C, Del Regno L, Peris K (2016) Drug-induced hair colour changes. Eur J Dermatol 26(6):531–536PubMedCrossRefGoogle Scholar
  72. Rodrigues M, Bekhor P (2015) Treatment of minocycline-induced cutaneous pigmentation with the picosecond alexandrite (755-nm) laser. Dermatol Surg 41(10):1179–1182PubMedCrossRefGoogle Scholar
  73. Rordam OM, Lenouvel EW, Maalo M (2012) Successful treatment of extensive vitiligo with monobenzone. J Clin Aesthet Dermatol 5(12):36PubMedPubMedCentralGoogle Scholar
  74. Roujeau JC, Bioulac-Sage P, Bourseau C, Guillaume JC, Bernard P, Lok C, Wechsler J (1991) Acute generalized exanthematous pustulosis: analysis of 63 cases. Arch Dermatol 127(9):1333–1338PubMedCrossRefGoogle Scholar
  75. Salavastru CM (2016) Approach to the evaluation and management of drug eruptions. Curr Dermatol Rep 5(1):49–57CrossRefGoogle Scholar
  76. Schneider JA, Cohen PR (2017) Stevens-Johnson syndrome and toxic epidermal necrolysis: a concise review with a comprehensive summary of therapeutic interventions emphasizing supportive measures. Adv Ther 4(6):1235–1244CrossRefGoogle Scholar
  77. Schwartz RA, McDonough PH, Lee BW (2013) Toxic epidermal necrolysis: Part II Prognosis, sequelae, diagnosis, differential diagnosis, prevention, and treatment. J Am Acad Dermatol 69(2):187.e1–187.e16CrossRefGoogle Scholar
  78. Scully C (2003) Drug effects on salivary glands: dry mouth. Oral Dis 9(4):165–176PubMedCrossRefPubMedCentralGoogle Scholar
  79. Sehgal VN, Jain S, Bhattacharya SN (1993) Cutaneous drug reactions. J Eur Acad Dermatol Venereol 2(4):281–295CrossRefGoogle Scholar
  80. Sehgal VN, Srivastava G, Sharma S, Sehgal S, Verma P (2011) Lichenoid tissue reaction/interface dermatitis: recognition, classification, etiology, and clinicopathological overtones. Indian J Dermatol Venereol Leprol 77(4):418–429PubMedCrossRefGoogle Scholar
  81. Shimizu Y, Kataoka M, Seto H, Kido JI, Nagata T (2002) Nifedipine induces gingival epithelial hyperplasia in rats through inhibition of apoptosis. J Periodontol 73(8):861–867PubMedCrossRefGoogle Scholar
  82. Shimoda K, Ikeda T, Okawara S, Kato M (2000) Possible relationship between phototoxicity and photodegradation of sitafloxacin, a quinolone antibacterial agent, in the auricular skin of albino mice. Toxicol Sci 56(2):290–296PubMedCrossRefGoogle Scholar
  83. Shiohara T (2009) Fixed drug eruption: pathogenesis and diagnostic tests. Curr Opin Allergy Clin Immunol 9(4):316–321PubMedCrossRefGoogle Scholar
  84. Sidoroff A, Halevy S, Bavinck JNB, Vaillant L, Roujeau JC (2001) Acute generalized exanthematous pustulosis (AGEP)–a clinical reaction pattern. J Cutan Pathol 28(3):113–119PubMedCrossRefGoogle Scholar
  85. Sidoroff A, Dunant A, Viboud C, Halevy S, Bavinck JN, Naldi L, Roujeau JC (2007) Risk factors for acute generalized exanthematous pustulosis (AGEP)- results of a multinational case–control study (EuroSCAR). Br J Dermatol 157(5):989–996PubMedCrossRefGoogle Scholar
  86. Singh G, Hodgson T, Clarke DE (2017) Leukocytoclastic vasculitis secondary to pyridostigmine (Mestinon): report of a possible first case. Perm J 21:15–240PubMedGoogle Scholar
  87. Skowron F, Bensaid B, Balme B, Depaepe L, Kanitakis J, Nosbaum A, Nicolas JF (2015) Drug reaction with eosinophilia and systemic symptoms (DRESS): clinicopathological study of 45 cases. J Eur Acad Dermatol Venereol 29(11):2199–2205PubMedCrossRefGoogle Scholar
  88. Stavropoulos PG, Soura E, Antoniou C (2014) Drug-induced pemphigoid: a review of the literature. J Eur Acad Dermatol Venereol 28(9):1133–1140PubMedCrossRefGoogle Scholar
  89. Stefanato CM (2010) Histopathology of alopecia: a clinicopathological approach to diagnosis. Histopathology 56(1):24–38PubMedCrossRefGoogle Scholar
  90. Stege H, Berneburg M, Humke S, Klammer M, Grewe M, Grether-Beck S, Boedeker R, Diepgen T, Dierks K, Goerz G, Ruzicka T, Krutmann J (1997) High-dose UVA1 radiation therapy for localized scleroderma. J Am Acad Dermatol 36(6 Pt 1):938–944PubMedCrossRefGoogle Scholar
  91. Sunita, Gupta DK, Saluja S, Bhasin S, Sharma M (2006) Imatinib mesylate-induced generalized hypopigmentation in patients with chronic myeloid leukemia. Indian J Pharmacol 38:66–67CrossRefGoogle Scholar
  92. Svensson CK, Cowen EW, Gaspari AA (2001) Cutaneous drug reactions. Pharmacol Rev 53(3):357–379PubMedGoogle Scholar
  93. Tamam L, Annagur BB (2006) Black hairy tongue associated with olanzapine treatment. Mt Sinai J Med 73(6):891–894PubMedGoogle Scholar
  94. Tsai MS, Yang CJ, Lee NY, Hsieh SM, Lin YH, Sun HY, Sheng WH, Lee KY, Yang SP, Liu WC, Wu PY, Ko WC, Hung CC (2014) Jarisch-Herxheimer reaction among HIV-positive patients with early syphilis: azithromycin versus benzathine penicillin G therapy. J Int AIDS Soc 17:18993PubMedPubMedCentralCrossRefGoogle Scholar
  95. Vecchietti G, Kerl K, Prins C, Kaya G, Saurat JH, French LE (2006) Severe eczematous skin reaction after high-dose intravenous immunoglobulin infusion: report of 4 cases and review of the literature. Arch Dermatol 142(2):213–217PubMedCrossRefGoogle Scholar
  96. Vena GA, Cassano N, Coco V, De Simone C (2013) Eczematous reactions due to angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers. Immunopharmacol Immunotoxicol 35(3):447–450PubMedCrossRefGoogle Scholar
  97. Verea MM, Pozo JD, Yebra-Pimentel MT, Porta A, Fonseca E (2004) Psoriasiform eruption induced by infliximab. Ann Pharmacother 38(1):54–57PubMedCrossRefGoogle Scholar
  98. Wendelin DS, Pope DN, Mallory SB (2003) Hypertrichosis. J Am Acad Dermatol 48(2):161–179PubMedCrossRefGoogle Scholar
  99. Whitworth JM, Thomas I, Peltz A, Sullivan BC, Wolf AH, Cytryn AS (1996) Vancomycin-induced linear IgA bullous dermatosis (LABD). J Am Acad Dermatol 34(5 Pt 2):890–891PubMedCrossRefGoogle Scholar
  100. Wilson BD, Beutner EH, Kumar V, Chorzelski TP, Jablonska S (1985) Linear IgA bullous dermatosis. Int J Dermatol 24(9):569–574PubMedCrossRefGoogle Scholar
  101. Wu H, Brandling-Bennett HA, Harrist TJ (2009) Noninfectious vesiculobullous and vesiculopustular diseases. In: Elder DE (ed) Lever’s histopathology of the skin, 10th edn. Lippincott Williams & Wilkins, Philadelphia, pp 235–278Google Scholar
  102. Yeager CE, Olsen EA (2011) Treatment of chemotherapy-induced alopecia. Dermatol Ther 24(4):432–442PubMedCrossRefGoogle Scholar
  103. Zuberbier T, Henz BM, Greaves MW, Juhlin L, Kobza-Black A, Maurer D, Stingl G (2001) Definition, classification, and routine diagnosis of urticaria: a consensus report. J Investig Dermatol Symp Proc 6(2):123–127PubMedCrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • George-Sorin Tiplica
    • 1
  • Carmen Maria Salavastru
    • 2
  • Ionela Manole
    • 3
    Email author
  • Mihaela Tovaru
    • 4
  1. 1.Colentina Clinical Hospital, 2nd Clinic of DermatologyCarol Davila University of Medicine and PharmacyBucharestRomania
  2. 2.Colentina Clinical Hospital, Department of Paediatric DermatologyCarol Davila University of Medicine and PharmacyBucharestRomania
  3. 3.Colentina Clinical HospitalThe Second Clinic of DermatologyBucharestRomania
  4. 4.Clinical Hospital of Infectious and Tropical Diseases “Dr. Victor Babes,”Clinic of DermatologyBucharestRomania

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