Treatment of Graves’ Disease

  • Luigi BartalenaEmail author
Reference work entry
Part of the Endocrinology book series (ENDOCR)


Treatment of hyperthyroidism due to Graves’ disease relies on the use of antithyroid drugs, radioiodine treatment, or thyroidectomy. None of these treatments are perfect, because they are not therapies targeting pathogenic mechanisms of the disease. Selection of either treatment is based on several criteria, but the choice should be shared with the informed patient. The major extrathyroidal manifestation of Graves’ disease, i.e., Graves’ orbitopathy, when moderate and active should be treated with high doses of intravenous glucocorticoids. This chapter provides an overview of treatment options for both hyperthyroidism and extrathyroidal manifestations, underscoring advantages and disadvantages of therapies, as well as preferred strategies in case of under particular circumstances, such as pregnancy and childhood.


Graves’ hyperthyroidism Antithyroid drugs Thionamides Methimazole Propylthiouracil Radioiodine Thyroidectomy Pregnancy Childhood Subclinical hyperthyroidism Graves’ orbitopathy Thyroid dermopathy 


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Medicine and SurgeryUniversity of Insubria, Endocrine Unit, ASST dei Sette Laghi, Ospedale di CircoloVareseItaly

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