Central Hypothyroidism

  • Andrea LaniaEmail author
  • Claudia Giavoli
  • Paolo Beck-Peccoz
Reference work entry
Part of the Endocrinology book series (ENDOCR)


Central hypothyroidism (CH) is a clinical condition characterized by a defect in thyroid hormone secretion due to an insufficient stimulation by thyrotropin (TSH) of an otherwise normal thyroid gland. CH is a rare and heterogeneous disorder that is caused by abnormalities of either the pituitary gland or the hypothalamus, and it may be congenital or acquired. The clinical manifestations are usually milder than those observed in primary hypothyroidism, and the CH diagnosis is based on low circulating levels of free thyroid hormone and low/normal TSH. CH treatment is based on L-thyroxine (L-T4) supplementation, the adequacy of which is evaluated by measuring circulating free thyroxine (FT4). This chapter analyzes our current understanding of the causes of CH and highlights possible pitfalls in its diagnosis and treatment.


Central hypothyroidism L-thyroxine Hypopituitarism 


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Andrea Lania
    • 1
    Email author
  • Claudia Giavoli
    • 2
  • Paolo Beck-Peccoz
    • 3
  1. 1.Department of Medical SciencesHumanitas University and Endocrinology Unit, Humanitas Research HospitalRozzanoItaly
  2. 2.Endocrinology and Metabolic Diseases UnitFondazione IRCCS Cà Granda-Ospedale MaggioreMilanoItaly
  3. 3.University of MilanMilanoItaly

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