Multiple Myeloma in Older Adults

  • Ashley RoskoEmail author
  • Geetika Bhatt
  • Eben Lichtman
  • Sascha Tuchman
Living reference work entry


Multiple myeloma (MM) is a plasma cell malignancy of older adults and incidence is expected to increase in the coming years. Despite substantial improvements in patient survival, the disease remains incurable. Early mortality is most common in adults 70 years and older. Novel therapeutics and autologous stem cell transplant (ASCT) have led to improvement in survival; however, transplant eligibility remains a challenge especially in the older adult population. Understanding geriatric assessment evaluations can aid in identifying patients at risk for increased morbidity and mortality in older adults with MM. Novel treatment combinations have improved disease control while balancing efficacy with toxicity for the older adult. Here we explore the diagnostic criteria, staging systems, cytogenetic abnormalities, treatment approach, and geriatric assessment in older adults with MM.


Multiple myeloma Autologous stem cell transplant Geriatric assessment 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Ashley Rosko
    • 1
    Email author
  • Geetika Bhatt
    • 2
  • Eben Lichtman
    • 3
  • Sascha Tuchman
    • 3
  1. 1.Division of HematologyThe Ohio State UniversityColumbusUSA
  2. 2.University Hospitals Seidman Cancer CenterCase Western Reserve UniversityClevelandUSA
  3. 3.Division of Hematology and OncologyUniversity of North Carolina – Chapel Hill Comprehensive Cancer CenterChapel HillUSA

Section editors and affiliations

  • Heidi Klepin
    • 1
  1. 1.Comprehensive Cancer Center of Wake Forest UniversityWinston-SalemUSA

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