Advertisement

Treatment of Local Disease in Testicular Cancer

  • Julia Heinzelbecker
Living reference work entry

Abstract

The primary treatment of local disease in testicular cancer has hardly changed during the last 100 years. High inguinal orchiectomy still represents the standard of care. The histological results of the operation together with the staging analysis and tumor markers form the basis for the further adjuvant treatment of testicular cancer. The implementation of a biopsy of the contralateral testis at the time of inguinal orchiectomy for the diagnosis or exclusion of germ cell neoplasia in situ (GCNIS) still remains controversial. In specific conditions such as synchronous and metachronous testicular cancer or a solitary testis, testis-sparing surgery followed by radiation therapy has gained wide acceptance. At the time of inguinal orchiectomy, the implantation of a testicular prosthesis can be offered safely to the patient.

References

  1. Albers P, Albrecht W, Algaba F, Bokemeyer C, Cohn-Cedermark G, Fizazi K, Horwich A, Laguna MP, Nicolai N, Oldenburg J. Guidelines on testicular cancer: 2015 update. Eur Urol. 2015;68:1054–68.CrossRefPubMedGoogle Scholar
  2. Bodiwala D, Summerton D, Terry T. Testicular prostheses: development and modern usage. Ann R Coll Surg Engl. 2007;89:349–53.CrossRefPubMedPubMedCentralGoogle Scholar
  3. Capelouto CC, Clark PE, Ransil BJ, Loughlin KR. A review of scrotal violation in testicular cancer: is adjuvant local therapy necessary? J Urol. 1995;153:981–5.CrossRefPubMedGoogle Scholar
  4. Dieckmann K-P, Kulejewski M, Heinemann V, Loy V. Testicular biopsy for early cancer detection – objectives, technique and controversies. Int J Androl. 2011;34:e7–13.CrossRefPubMedGoogle Scholar
  5. Dieckmann K-P, Anheuser P, Schmidt S, Soyka-Hundt B, Pichlmeier U, Schriefer P, Matthies C, Hartmann M, Ruf CG. Testicular prostheses in patients with testicular cancer – acceptance rate and patient satisfaction. BMC Urol. 2015;15Google Scholar
  6. Giannarini G, Dieckmann K-P, Albers P, Heidenreich A, Pizzocaro G. Organ-sparing surgery for adult testicular tumours: a systematic review of the literature. Eur Urol. 2010;57:780–90.CrossRefPubMedGoogle Scholar
  7. Heidenreich A. Contralateral testicular biopsy in testis cancer: current concepts and controversies. BJU Int. 2009;104:1346–50.CrossRefPubMedGoogle Scholar
  8. Heidenreich A, Weissbach L, Höltl W, Albers P, Kliesch S, Köhrmann KU, DIeckmann KP, German Testicular Cancer Study Group. Organ sparing surgery for malignant germ cell tumor of the testis. J Urol. 2001;166:2161–5.CrossRefPubMedGoogle Scholar
  9. Neal RD, Tharmanathan P, France B, Din NU, Cotton S, Fallon-Ferguson J, Hamilton W, Hendry A, Hendry M, Lewis R, et al. Is increased time to diagnosis and treatment in symptomatic cancer associated with poorer outcomes? Systematic review. Br J Cancer. 2015;112:S92–S107.CrossRefPubMedPubMedCentralGoogle Scholar
  10. Robinson R, Tait CD, Clarke NW, Ramani VAC. Is it safe to insert a testicular prosthesis at the time of radical orchidectomy for testis cancer: an audit of 904 men undergoing radical orchidectomy. BJU Int. 2016;117:249–52.CrossRefPubMedGoogle Scholar
  11. Woo LL, Ross JH. The role of testis-sparing surgery in children and adolescents with testicular tumors. Urol Oncol Semin Orig Investig. 2016;34:76–83.CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Urology and Pediatric UrologySaarland University Medical CenterHomburg/SaarGermany

Section editors and affiliations

  • Chris Protzel
    • 1
  • Axel Heidenreich
    • 2
  1. 1.Universitätsklinikum Rostock , Urologische Klinik und PoliklinikRostockGermany
  2. 2.Division of Oncological Urology, Department of UrologyUniversity of KölnKölnGermany

Personalised recommendations