Paget’s Disease of the Anus
Paget’s disease is a rare intraepithelial adenocarcinoma that may occur in the perianal skin. Its histogenesis is not completely understood. Paget’s disease could represent the epidermotropic spread of tumor cells from cancers of regional organs and from adenocarcinoma of skin adnexa such as eccrine or apocrine glands. It could also originate from an intraepidermal ectopic sweat gland or Bartholin’s glands’ epithelial cells or could originate from an in situ transformation of a pluripotential stem cell within the epidermis.
Perianal Paget’s disease was first reported in 1893 by Darier and Coulillaud. It encompasses two entities: primary and secondary Paget’s disease.
Secondary perianal Paget’s disease represents half of the cases. It results from the epidermotropic spread of an underlying neoplasm such as adnexal adenocarcinoma or an internal malignancy mainly gastrointestinal carcinoma (usually anal or rectal cancer) or genitourinary carcinoma (mainly urethral carcinoma)....
References and Further Reading
- Shia, J. (2010). An update on tumors of the anal canal. Archives of Pathology & Laboratory Medicine, 134, 1601–1611.Google Scholar