Metaplasia is a reversible change in which one adult cell type (epithelial or mesenchymal) is replaced by another adult cell type. Intestinal metaplasia (IM) of the stomach is a relatively frequent preneoplastic lesion resulting from the replacement of the gastric epithelium by an intestinal-like epithelium as a result of chronic injury. Colonization of the gastric mucosa with Helicobacter pylori is the main risk factor for IM and gastric cancer development, and it has been categorized by the International Agency for Research on Cancer as a type I carcinogen. This is one of the most common bacterial infections in humans with a prevalence that reaches 90% in many developing countries and a lower prevalence in developed ones that, nevertheless, varies between 30% and 50%.
IM appears following H. pyloriinfection and chronic inflammation, as part of a multistep precancerous process that was first described in 1975, by Pelayo Correa, based on observations in...
References and Further Reading
- Capelle, L. G., de Vries, A. C., Haringsma, J., Ter Borg, F., de Vries, R. A., Bruno, M. J., van Dekken, H., Meijer, J., van Grieken, N. C., & Kuipers, E. J. (2010). The staging of gastritis with the OLGA system by using intestinal metaplasia as an accurate alternative for atrophic gastritis. Gastrointestinal Endoscopy, 71, 1150–1158.CrossRefPubMedGoogle Scholar
- Mesquita, P., Almeida, R., Lunet, N., Reis, C. A., Silva, L. F., Serpa, J., Van Seuningen, I., Barros, H., & David, L. (2006). Metaplasia–a transdifferentiation process that facilitates cancer development: The model of gastric intestinal metaplasia. Critical Reviews in Oncogenesis, 12, 3–26.CrossRefPubMedGoogle Scholar
- Reis, C. A., David, L., Correa, P., Carneiro, F., de Bolós, C., Garcia, E., Mandel, U., Clausen, H., & Sobrinho-Simões, M. (1999). Intestinal metaplasia of human stomach displays distinct patterns of mucin (MUC1, MUC2, MUC5AC, and MUC6) expression. Cancer Research, 59, 1003–1007.PubMedGoogle Scholar