Gastric xanthelasma is a sharply demarcated yellowish accumulation of lipid-containing macrophages (xanthomatous cells) within the gastric mucosa. They may develop in the setting of cholestasis and hypercholesterolemia.
The reported prevalence of upper gastrointestinal xanthelasma is 0.23%. Approximately 76% of the lesions are located in the stomach, particularly in the antrum and the pyloric region (70%).
The incidence increases with age, reaching the highest values between 40 and 60 years of age.
Xanthelasma seems to be more frequent in women, though there are some discrepancies in the literatures regarding gender predilection.
Most lesions localize in the antrum and the pylorus.
The lesion itself does not cause symptoms and does not need treatment. However, it is often associated with duodenal reflux, chronic gastritis, gastric surgery, or even cancer. The treatment of the primary...