Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Cameron’s Ulcer

  • Pedro Pimentel-NunesEmail author
  • Ricardo Marcos-Pinto
  • Mário Dinis-Ribeiro
Reference work entry


Cameron erosions; Cameron lesions


Cameron lesions are benign, superficial, and linear erosions or ulcers associated with gastroesophageal hiatal hernia, generally large hernias. They are named in tribute of Adrian J Cameron who in 1986 first described these lesions as a cause of anemia in patients with hiatal hernias. The lesions are located in the proximal body of the stomach at the end of the hernia, near the diaphragmatic impression. They are thought to be caused primarily by mechanical trauma and local ischemia caused by the repeated movements of the diaphragm against the hernia. Secondarily, acid and pepsin may perpetuate the lesions. They are a rare cause of overt gastric bleeding; however, they are a common cause of obscure gastrointestinal bleeding and of ferropenic anemia in patients with hiatal hernias.

Clinical Features

  • Incidence

    Cameron lesions are uncommon, with an estimated incidence of 5% in patients with hiatal hernia. The risk is around 10–20% when...

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References and Further Reading

  1. Byron, C., & Stuart, J. S. (2010). Peptic ulcer disease. Sleisenger & Fordtran’s gastrointestinal and liver disease. (9th ed.). Saunders: Elsevier.Google Scholar
  2. Cameron, A. J., & Higgins, J. A. (1986). Linear gastric erosion. A lesion associated with large diaphragmatic hernia and chronic blood loss anemia. Gastroenterology, 91, 338–342.PubMedGoogle Scholar
  3. Maganty, K., & Smith, R. L. (2008). Cameron lesions: Unusual cause of gastrointestinal bleeding and anemia. Digestion, 77, 214–217.PubMedGoogle Scholar
  4. Moskovitz, M., Fadden, R., Min, T., Jansma, D., & Gavaler, J. (1992). Large hiatal hernias, anemia, and linear gastric erosion: Studies of etiology and medical therapy. The American Journal of Gastroenterology, 87, 622–626.PubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Pedro Pimentel-Nunes
    • 1
    • 3
    Email author
  • Ricardo Marcos-Pinto
    • 1
    • 2
  • Mário Dinis-Ribeiro
    • 1
    • 3
  1. 1.Serviço de GastrenterologiaPortuguese Oncology InstitutePortoPortugal
  2. 2.Centro Hospitalar do PortoInstituto de Ciências Biomédicas Abel Salazar (ICBAS-UP), Cintesis (FMUP-UP)PortoPortugal
  3. 3.Instituto Português de Oncologia (IPO - Porto), Cintesis (FMUP-UP)PortoPortugal