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Pathology of the Gastrointestinal Tract pp 659–662Cite as

Tubular Adenocarcinoma

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Intestinal-type adenocarcinoma

Definition

Tubular adenocarcinoma is one of the five main types of gastric adenocarcinoma in the WHO classification scheme and represents the most common type of gastric adenocarcinoma. Together with papillary carcinoma and (part of) mucinous carcinoma, tubular carcinoma represents intestinal-type adenocarcinoma in the Laurén classification. Tubular adenocarcinomas are made up of simple or branching tubules resembling colorectal carcinoma and less commonly small, acinar structures sometimes resembling antral glands.

Gastric cancer has a complex pathogenesis, in which several factors are involved including a familial risk and environmental factors, with the strongest known risk factor being chronic gastritis induced by H. pylori infection. In 1994, the WHO classified H. pylorias a class I carcinogen based mainly on epidemiological evidence for its role in the pathogenesis of gastric adenocarcinoma. Several bacterial virulence factors define the...

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References and Further Reading

  • Allum, W. H., Blazeby, J. M., Griffin, S. M., Cunningham, D., Jankowski, J. A., & Wong, R. (2011). Guidelines for the management of oesophageal and gastric cancer. Gut, 60(11), 1449–1472.

    Article  CAS  Google Scholar 

  • Bosman, F. T., Carneiro, F., Hruban, R. H., & Theise, N. D. (2010). WHO classification of tumours of the digestive system (4th ed.). Lyon: IARC.

    Google Scholar 

  • Cancer Genome Atlas Research, N. (2014). Comprehensive molecular characterization of gastric adenocarcinoma. Nature, 513(7517), 202–209.

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  • Ferlay, J., Soerjomataram, I., Ervik, M., et al. (2013). GLOBOCAN 2012 v1.0, cancer incidence and mortality worldwide. IARC CancerBase 11. International Agency for Research on Cancer (http://globocan.iarc.fr)

  • Price, T. J., Shapiro, J. D., Segelov, E., Karapetis, C. S., Pavlakis, N., Van Cutsem, E., et al. (2012). Management of advanced gastric cancer. Expert Review of Gastroenterology & Hepatology, 6(2), 199–208. quiz 209.

    Article  CAS  Google Scholar 

  • Wong, H., & Yau, T. (2013). Molecular targeted therapies in advanced gastric cancer: Does tumor histology matter? Therapeutic Advances in Gastroenterology, 6(1), 15–31.

    Article  CAS  Google Scholar 

  • Zang, Z. J., Cutcutache, I., Poon, S. L., Zhang, S. L., McPherson, J. R., Tao, J., et al. (2012). Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. Nature Genetics, 44(5), 570–574.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pathology, Radboud University Medical Center, Postbox 9101, 6500 HB, Nijmegen, The Netherlands

    Chella R. S. van der Post

  2. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

Authors
  1. Chella R. S. van der Post
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  2. Fátima Carneiro
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Corresponding author

Correspondence to Chella R. S. van der Post .

Editor information

Editors and Affiliations

  1. Faculty of Medicine of Porto University, Centro Hospitalar São João and Ipatimup/i3S, Porto, Portugal

    Fátima Carneiro

  2. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa de Francisco Gentil, Lisbon, Portugal

    Paula Chaves

  3. Faculdade de Ciências da Saúde, Universidade da Beira Interior, Covilhã, Portugal

    Paula Chaves

  4. Department of Pathology, Ankara University Medical School, Sihhiye, Ankara, Turkey

    Arzu Ensari

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van der Post, C.R.S., Carneiro, F. (2017). Tubular Adenocarcinoma. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1687

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  • DOI: https://doi.org/10.1007/978-3-319-40560-5_1687

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-40559-9

  • Online ISBN: 978-3-319-40560-5

  • eBook Packages: MedicineReference Module Medicine

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