Signet Ring Cell Carcinoma
Diffuse carcinoma; Poorly cohesive carcinoma
Signet ring cell carcinoma is defined as a tumor composed predominantly (more than 50%) or exclusively of signet ring cells, characterized histologically by cells with a large vacuolated mucinous cytoplasm and an eccentrically placed flattened nucleus.
Various classification schemes for gastric cancer have been proposed; the Laurén and the World Health Organization (WHO) classification systems are the most widely used. Gastric adenocarcinomas are subtyped in the WHO classification based on the predominant morphologic component of the tumor. These subtypes include tubular, papillary, mucinous, poorly cohesive (including signet-ring cell type), and mixed carcinomas. The Laurén scheme separates gastric adenocarcinomas into intestinal, diffuse, and mixed or indeterminate subtypes. Signet ring cell carcinomas are categorized into the diffuse type in the Laurén scheme.
Gastric adenocarcinoma is the...
References and Further Reading
- Bosman, F. T., Carneiro, F., Hruban, R. H., & Theise, N. D. (2010). WHO classification of tumours of the digestive system (4th ed.). Lyon: IARC.Google Scholar
- Heger, U., Blank, S., Wiecha, C., Langer, R., Weichert, W., Lordick, F., Bruckner, T., Dobritz, M., Burian, M., Springfeld, C., Grenacher, L., Siewert, J. R., Büchler, M., & Ott, K. (2014). Is preoperative chemotherapy followed by surgery the appropriate treatment for signet ring cell containing adenocarcinomas of the esophagogastric junction and stomach?Google Scholar
- Koyama, T., Sekine, S., Taniguchi, H., Tsuda, H., Ikegami, M., Hano, H., & Kushima, R. (2011). Hepatocyte nuclear factor 4A expression discriminates gastric involvement by metastatic breast carcinomas from primary gastric adenocarcinomas. Human Pathology, 42(11), 1777–1784.CrossRefPubMedGoogle Scholar
- Messager, M., Lefevre, J. H., Pichot-Delahaye, V., Souadka, A., Piessen, G., & Mariette, C. (2011). The impact of perioperative chemotherapy on survival in patients with gastric signet ring cell adenocarcinoma: a multicenter comparative study. Ann Surg, 254, 684–693.Google Scholar