Pyloric Gland Adenoma
Pyloric gland adenomas (PGAs) are localized epithelial neoplastic growths with pyloric differentiation (Park et al. 2012). They were first described in 1976 by Elster but misinterpreted as adenoma-like hyperplasia of mucous glands. In 1990, Borchard et al. published the first characterization of two cases with mucin analysis. Although 85% are found in the stomach, 15% are found in extra-gastric locations (Vieth et al. 2003). Like intestinal-type adenomas, pyloric gland adenomas can arise in a background of autoimmune gastritis and Helicobacter pylori infection (Lash et al. 2011). Even if rare, PGAs are precancerous lesions and frequently associated with high-grade dysplasia and adenocarcinoma (Kushima et al. 2006; Vieth et al. 2003).
References and Further Reading
- Lash, R. H., Kinsey, S., Genta, R. M., & Lauwers, G. Y. (2011). Gastric polyps. In D. Tan & G. Y. Lauwers (Eds.), Advances in surgical pathology gastric cancer (pp. 308–309). Philadelphia: Lippincott Williams & Wilkins.Google Scholar
- Park, J. Y., Fenton, H., Lewin, M., & Dilworth, H. (2012). Epithelial neoplasms of the stomach. In C. A. Iacobuzio-Donahue, E. Montgomary, & J. R. Golblum (Eds.), Gastrointestinal and liver pathology (pp. 148–150). Philadelphia: Saunders.Google Scholar