Pathology of the Gastrointestinal Tract

2017 Edition
| Editors: Fátima Carneiro, Paula Chaves, Arzu Ensari

Pyloric Gland Adenoma

  • Helena Baldaia
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-40560-5_1675

Synonyms

Gastric-type adenoma

Definition

Pyloric gland adenomas (PGAs) are localized epithelial neoplastic growths with pyloric differentiation (Park et al. 2012). They were first described in 1976 by Elster but misinterpreted as adenoma-like hyperplasia of mucous glands. In 1990, Borchard et al. published the first characterization of two cases with mucin analysis. Although 85% are found in the stomach, 15% are found in extra-gastric locations (Vieth et al. 2003). Like intestinal-type adenomas, pyloric gland adenomas can arise in a background of autoimmune gastritis and Helicobacter pylori infection (Lash et al. 2011). Even if rare, PGAs are precancerous lesions and frequently associated with high-grade dysplasia and adenocarcinoma (Kushima et al. 2006; Vieth et al. 2003).

Clinical Features

  • Incidence

    In one study, in a period of 10 years, pyloric gland adenomas corresponded to 2.7% of all gastric polyps (Vieth et al. 2003).

  • Age

    The peak age at diagnosis is in the seventh decade (73 ±...

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References and Further Reading

  1. Chen, Z. M., Scudiere, J. R., Abraham, S. C., & Montgomery, E. (2009). Pyloric gland adenoma: An entity distinct from gastric foveolar type adenoma. American Journal of Surgical Pathology, 33(2), 186–193.CrossRefPubMedGoogle Scholar
  2. Kushima, R., Vieth, M., Borchard, F., et al. (2006). Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach. Gastric Cancer, 9(3), 177–184.CrossRefPubMedGoogle Scholar
  3. Lash, R. H., Kinsey, S., Genta, R. M., & Lauwers, G. Y. (2011). Gastric polyps. In D. Tan & G. Y. Lauwers (Eds.), Advances in surgical pathology gastric cancer (pp. 308–309). Philadelphia: Lippincott Williams & Wilkins.Google Scholar
  4. Park, J. Y., Fenton, H., Lewin, M., & Dilworth, H. (2012). Epithelial neoplasms of the stomach. In C. A. Iacobuzio-Donahue, E. Montgomary, & J. R. Golblum (Eds.), Gastrointestinal and liver pathology (pp. 148–150). Philadelphia: Saunders.Google Scholar
  5. Vieth, M., Kushima, R., Borchard, F., & Stolte, M. (2003). Pyloric gland adenoma: A clinico-pathological analysis of 90 cases. Virchows Archiv, 442(4), 317–321.PubMedGoogle Scholar
  6. Vieth, M., Kushima, R., Mukaisho, K., Sakai, R., et al. (2010). Immunohistochemical analysis of pyloric gland adenomas using a series of Mucin 2, Mucin 5AC, Mucin 6, CD10, Ki67 and p53. Virchows Archiv, 457(5), 529–536.CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  1. 1.Serviço de Anatomia PatológicaCentro Hospitalar de São JoãoPortoPortugal