Synonyms
Paterson-Brown-Kelly syndrome; Paterson-Kelly syndrome; Sideropenic dysphagia; Waldenström and Kjellberg syndrome
Definition
Plummer-Vinson syndrome is the most common name attributed to the association of dysphagia, upper esophageal webs, and iron-deficiency anemia. Henry Stanley Plummer and Porter Paisley Vinson were the American physicians who first reported clinical cases of patients with this entity. However, its full description was done later by the British laryngologists Donald Ross Paterson and Adam Brown-Kelly. Waldenström and Kjellberg later documented cases of the syndrome also occurring with sideropenia without anemia.
The pathogenesis of Plummer-Vinson syndrome (PVS) remains unknown, but the main purposed theories are based on nutritional deficiencies (mainly of iron) or autoimmune phenomenon. The syndrome’s diagnosis implies iron deficiency, with or without anemia, and this deficiency is proposed to lead both to atrophy of the esophageal mucosa, with formation...
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References and Further Reading
Geerlings, S. F., & van Eps, L. W. S. (1992). Pathogenesis and consequences of Plummer-Vinson syndrome. The Clinical Investigator, 70, 629–630.
Hoffman, R. M., & Jaffe, P. E. (1995). Plummer-Vinson syndrome. A case report and literature review. Archives of Internal Medicine, 155, 2008–2011.
Novacek, G. (2006). Plummer-Vinson syndrome. Orphanet Journal of Rare Diseases, 1, 36.
Popescu, C. R., Bertesteanu, S. V. G., Mirea, D., Grigore, R., Ionescu, D., & Popescu, B. (2010). The epidemiology of hypopharynx and cervical esophagus cancer. Journal of Medicine and Life, 3, 396–401.
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Rosa, I., Pereira, A.D. (2017). Plummer-Vinson Syndrome. In: Carneiro, F., Chaves, P., Ensari, A. (eds) Pathology of the Gastrointestinal Tract. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-40560-5_1670
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DOI: https://doi.org/10.1007/978-3-319-40560-5_1670
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